Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European CohortVisa övriga samt affilieringar
2020 (Engelska)Ingår i: Movement Disorders, ISSN 0885-3185, E-ISSN 1531-8257, Vol. 35, nr 7, s. 1258-1263Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.
Objective: To assess the associations between alcohol consumption and PD risk.
Methods: Within NeuroEPIC4PD, a prospective European population‐based cohort, 694 incident PD cases were ascertained from 209,998 PD‐free participants. Average alcohol consumption at different time points was self‐reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.
Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD.
Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.
Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2020. Vol. 35, nr 7, s. 1258-1263
Nyckelord [en]
alcohol, EPIC, epidemiology, Parkinson, prospective cohort
Nationell ämneskategori
Näringslära Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-170837DOI: 10.1002/mds.28039ISI: 000529674500001PubMedID: 32357270Scopus ID: 2-s2.0-85084214967OAI: oai:DiVA.org:umu-170837DiVA, id: diva2:1430527
2020-05-152020-05-152023-03-24Bibliografiskt granskad