Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Surgical treatment of breast cancer liver metastases: A nationwide registry-based case control study
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. Department of Surgery, Sunderby Hospital, Luleå, Sweden.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Show others and affiliations
2020 (English)In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 46, no 6, p. 1006-1012Article in journal (Refereed) Published
Abstract [en]

Introduction: The benefit of liver resection or ablation for breast cancer liver metastases (BCLM) remains unclear. The aim of the study was to determine survival after isolated BCLM in nationwide cohorts and compare surgical versus systemic treatment regimens.

Materials and methods: The Swedish register for cancer in the liver and the bile ducts (SweLiv) and the National register for breast cancer (NBCR) was studied to identify patients with 1-5 BCLM without extrahepatic spread diagnosed 2009-2016. Data from the registers were validated and completed by review of medical records. A Kaplan-Meier plot and log rank test were used to analyse survival. Prognostic and predictive factors were evaluated by Cox regression analysis.

Results: A surgical cohort (n = 29) was identified and compared to a control cohort (n = 33) receiving systemic treatment only. There was no 90-day mortality after surgery. Median survival from BCLM diagnosis was 77 months (95% CI 41-113) in the surgical cohort and 28 months (95% CI 13-43) in the control cohort, (p = 0.004). There was a longer disease-free interval and more oestrogen receptor positive tumours in the surgical cohort. Surgery was a significant positive predictive factor in univariate analysis while a multivariable analysis resulted in HR 0.478 (CI 0.193-1.181, p = 0.110) for surgical treatment.

Conclusion: Surgery for BCLM is safe and might provide a survival benefit in selected patients but prospective trials are warranted to avoid selection bias.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 46, no 6, p. 1006-1012
Keywords [en]
Breast cancer, Liver metastases, Liver resection, Liver ablation
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-172505DOI: 10.1016/j.ejso.2020.02.008ISI: 000537625100011PubMedID: 32098734Scopus ID: 2-s2.0-85079894172OAI: oai:DiVA.org:umu-172505DiVA, id: diva2:1451369
Available from: 2020-07-02 Created: 2020-07-02 Last updated: 2021-09-22Bibliographically approved

Open Access in DiVA

fulltext(1426 kB)157 downloads
File information
File name FULLTEXT01.pdfFile size 1426 kBChecksum SHA-512
3238589f1b1fd393e824d7142b1c958d509c73a26f34ef6c225d23493d42d85ecf335f8ca3c97797ee63d2288a8ffccb393bedcdf2ec118df8f360d8e857bcf5
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Andersson, AnneSund, MalinHemmingsson, Oskar

Search in DiVA

By author/editor
Sundén, MarcusAndersson, AnneSund, MalinHemmingsson, Oskar
By organisation
SurgeryOncology
In the same journal
European Journal of Surgical Oncology
Surgery

Search outside of DiVA

GoogleGoogle Scholar
Total: 157 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 308 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf