Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sleep apnea in men is associated with altered lipid metabolism, glucose tolerance, insulin sensitivity, and body fat percentage
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-1313-0934
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.ORCID iD: 0000-0002-5306-1697
Show others and affiliations
2020 (English)In: Endocrine, ISSN 1355-008X, E-ISSN 1559-0100, Vol. 70, p. 48-57Article in journal (Refereed) Published
Abstract [en]

Purpose: Obstructive sleep apnea (OSA) is associated with obesity and risk for type 2 diabetes. In this community-based study, we thoroughly investigated fatty acid metabolism, incretin response, glucose tolerance, insulin secretion and insulin sensitivity, and autonomic nerve activity in men with or without OSA.

Methods: Fifteen men without diabetes but with signs of severe OSA, defined as apnea–hypopnea index (AHI) >30, and 15 age- and BMI-matched men without OSA (AHI < 5) were recruited from a community-based cohort. Assessments included clinical and anthropometric measurements, a 2-h oral glucose tolerance test (OGTT), and autonomic nerve activity using heart rate variability (HRV).

Results: Men with OSA had higher body fat % than BMI-matched men without OSA (p = 0.046) and it was associated with markers of insulin resistance. The area under the curve for nonesterified fatty acids (NEFA) during OGTT was higher in men with OSA (p = 0.021) and fasting NEFA levels were numerically higher (p = 0.097). The plasma glucose at fasting and during OGTT was higher in men with OSA (p < 0.001). Incretin response was similar between groups. Fasting and OGTT-derived indices indicated impaired insulin sensitivity in men with OSA. Compared with men without OSA, Matsuda index (p = 0.068) and Gutt index (p < 0.01) were lower in men with OSA. The HRV measures did not differ between groups.

Conclusions: Our study suggests that fatty acid handling, glucose tolerance, and insulin sensitivity are impaired in men with severe OSA. This might partly be explained by the increased body fat percentage.

Place, publisher, year, edition, pages
Springer, 2020. Vol. 70, p. 48-57
Keywords [en]
Obstructive sleep apnea, Glucose metabolism, Lipid metabolism, Insulin secretion
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-173463DOI: 10.1007/s12020-020-02369-3ISI: 000541303800002PubMedID: 32562183Scopus ID: 2-s2.0-85086665134OAI: oai:DiVA.org:umu-173463DiVA, id: diva2:1453411
Funder
Swedish Heart Lung FoundationEXODIAB - Excellence of Diabetes Research in SwedenSwedish Diabetes AssociationErnfors FoundationAvailable from: 2020-07-10 Created: 2020-07-10 Last updated: 2023-08-28Bibliographically approved

Open Access in DiVA

fulltext(803 kB)167 downloads
File information
File name FULLTEXT02.pdfFile size 803 kBChecksum SHA-512
bdc25866faed2267e0aab8ffbbfefae62f5cf2ec404a53028d3b791fc60f4f7a75beaf87ad5986f17bc374febffb6c2548cb6ce896f9f48562b4e7eb952ae2d2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Wiklund, UrbanFranklin, Karl A.

Search in DiVA

By author/editor
Wiklund, UrbanFranklin, Karl A.
By organisation
Radiation PhysicsSurgery
In the same journal
Endocrine
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 223 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 304 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf