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Sleep apnea in men is associated with altered lipid metabolism, glucose tolerance, insulin sensitivity, and body fat percentage
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.ORCID-id: 0000-0002-1313-0934
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.ORCID-id: 0000-0002-5306-1697
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2020 (Engelska)Ingår i: Endocrine, ISSN 1355-008X, E-ISSN 1559-0100, Vol. 70, s. 48-57Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: Obstructive sleep apnea (OSA) is associated with obesity and risk for type 2 diabetes. In this community-based study, we thoroughly investigated fatty acid metabolism, incretin response, glucose tolerance, insulin secretion and insulin sensitivity, and autonomic nerve activity in men with or without OSA.

Methods: Fifteen men without diabetes but with signs of severe OSA, defined as apnea–hypopnea index (AHI) >30, and 15 age- and BMI-matched men without OSA (AHI < 5) were recruited from a community-based cohort. Assessments included clinical and anthropometric measurements, a 2-h oral glucose tolerance test (OGTT), and autonomic nerve activity using heart rate variability (HRV).

Results: Men with OSA had higher body fat % than BMI-matched men without OSA (p = 0.046) and it was associated with markers of insulin resistance. The area under the curve for nonesterified fatty acids (NEFA) during OGTT was higher in men with OSA (p = 0.021) and fasting NEFA levels were numerically higher (p = 0.097). The plasma glucose at fasting and during OGTT was higher in men with OSA (p < 0.001). Incretin response was similar between groups. Fasting and OGTT-derived indices indicated impaired insulin sensitivity in men with OSA. Compared with men without OSA, Matsuda index (p = 0.068) and Gutt index (p < 0.01) were lower in men with OSA. The HRV measures did not differ between groups.

Conclusions: Our study suggests that fatty acid handling, glucose tolerance, and insulin sensitivity are impaired in men with severe OSA. This might partly be explained by the increased body fat percentage.

Ort, förlag, år, upplaga, sidor
Springer, 2020. Vol. 70, s. 48-57
Nyckelord [en]
Obstructive sleep apnea, Glucose metabolism, Lipid metabolism, Insulin secretion
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
URN: urn:nbn:se:umu:diva-173463DOI: 10.1007/s12020-020-02369-3ISI: 000541303800002PubMedID: 32562183Scopus ID: 2-s2.0-85086665134OAI: oai:DiVA.org:umu-173463DiVA, id: diva2:1453411
Forskningsfinansiär
Hjärt-LungfondenEXODIAB - Excellence of Diabetes Research in SwedenDiabetesförbundetStiftelsen familjen Ernfors fondTillgänglig från: 2020-07-10 Skapad: 2020-07-10 Senast uppdaterad: 2023-08-28Bibliografiskt granskad

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Wiklund, UrbanFranklin, Karl A.

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