Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0002-2088-6756
Show others and affiliations
2020 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 21, no 11, article id 3978Article in journal (Refereed) Published
Abstract [en]

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

Place, publisher, year, edition, pages
MDPI, 2020. Vol. 21, no 11, article id 3978
Keywords [en]
endocrine-disrupting chemicals, developmental neurotoxicity, chemical testing, adverse outcome pathways
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-173602DOI: 10.3390/ijms21113978ISI: 000543400300240PubMedID: 32492937Scopus ID: 2-s2.0-85085876763OAI: oai:DiVA.org:umu-173602DiVA, id: diva2:1454835
Note

Special issue: Advances in the Research of Endocrine Disrupting Chemicals 2.0

Available from: 2020-07-20 Created: 2020-07-20 Last updated: 2023-03-23Bibliographically approved

Open Access in DiVA

fulltext(2324 kB)139 downloads
File information
File name FULLTEXT01.pdfFile size 2324 kBChecksum SHA-512
4be54a53630729717bcf81efe99f70647a7517f0446644b139eb2afeca38f94c198ae9f00d9fe6ef868731ffdcc275ef4c49ed133cd8574406a689778522997b
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Andersson, Patrik L.

Search in DiVA

By author/editor
Lupu, DianaAndersson, Patrik L.Gennings, ChrisLeonards, Pim E. G.
By organisation
Department of Chemistry
In the same journal
International Journal of Molecular Sciences
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 139 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 248 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf