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Hepcidin is a relevant iron status indicator in infancy: results from a randomized trial of early vs. delayed cord clamping
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics. Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).ORCID iD: 0000-0002-9263-9578
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
2021 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 89, no 5, p. 1216-1221Article in journal (Refereed) Published
Abstract [en]

Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants.

Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors.

Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference) was 64.5 (10.9–142.1), 39.5 (3.5–157.7), and 32.9 (11.2–124.2) ng/mL in the cord blood and at 4 and 12 months, respectively. The value of 16 ng/mL was a threshold detecting all cases of iron depletion/ID at 4 months. No similar threshold for ID was observed at 12 months. The strongest predictor of hepcidin at both ages was ferritin.

Conclusions: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID. Levels <16 ng/mL at 4 months of age indicates ID.

Impact

  • Serum hepcidin is a relevant indicator of iron status in early infancy.
  • Normal reference in healthy infants is suggested in this study.
  • Serum hepcidin may be useful in clinical practice to detect iron deficiency.
Place, publisher, year, edition, pages
Nature Publishing Group, 2021. Vol. 89, no 5, p. 1216-1221
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-173622DOI: 10.1038/s41390-020-1045-9ISI: 000545884400001PubMedID: 32610342Scopus ID: 2-s2.0-85087307303OAI: oai:DiVA.org:umu-173622DiVA, id: diva2:1455065
Funder
Swedish Research Council, 2019-01005Knut and Alice Wallenberg FoundationRegion VästerbottenAvailable from: 2020-07-22 Created: 2020-07-22 Last updated: 2022-04-04Bibliographically approved

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Berglund, Staffan K.Chmielewska, AnnaDomellöf, Magnus

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