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Patient-reported and doctor-reported symptoms when faecal immunochemical tests are requested in primary care in the diagnosis of colorectal cancer and inflammatory bowel disease: a prospective study
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi.ORCID-id: 0000-0001-8846-7681
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för medicin.ORCID-id: 0000-0002-5607-0118
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.ORCID-id: 0000-0002-5203-9877
2020 (Engelska)Ingår i: BMC Family Practice, E-ISSN 1471-2296, Vol. 21, nr 1, artikel-id 129Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Rectal bleeding and a change in bowel habits are considered to be alarm symptoms for colorectal cancer and they are also common symptoms for inflammatory bowel disease. However, most patients with these symptoms do not have any of these diseases. Faecal immunochemical tests (FITs) for haemoglobin are used as triage tests in Sweden and other countries but little is known about the symptoms patients have when FITs are requested.

Objective: Firstly, to determine patients’ symptoms when FITs are used as triage tests in primary care and whether doctors record the symptoms that patients report, and secondly to evaluate the association between symptoms, FIT results and possible prediction of colorectal cancer or inflammatory bowel disease.

Methods and materials: This prospective study included 364 consecutive patients for whom primary care doctors requested a FIT. Questionnaires including gastrointestinal symptoms were completed by patients and doctors.

Results: Concordance between symptoms reported from patients and doctors was low. Rectal bleeding was recorded by 43.5% of patients versus 25.6% of doctors, FITs were negative in 58.3 and 52.7% of these cases respectively. The positive predictive value (PPV) of rectal bleeding recorded by patients for colorectal cancer or inflammatory bowel disease was 9.9% (95% confidence interval [CI] 5.2–14.7); for rectal bleeding combined with a FIT the PPV was 22.6% (95% CI 12.2–33.0) and the negative predictive value (NPV) was 98.9% (95% CI 96.7–100). For patient-recorded change in bowel habits the PPV was 6.1% (95% CI 2.4–9.8); for change in bowel habits combined with a FIT the PPV was 18.2% (95% CI 9.1–30.9) and the NPV 100% (95% CI 90.3–100).

Conclusions: Doctors should be aware that, during consultations, they do not record all symptoms experienced by patients. FITs requested in primary care, when found positive, may potentially be of help in prioritising referrals, also when patients present with rectal bleeding or change in bowel habits.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2020. Vol. 21, nr 1, artikel-id 129
Nyckelord [en]
Colorectal neoplasms, Faecal immunochemical test, Gastrointestinal symptoms, Occult blood, Primary care, Rectal bleeding
Nationell ämneskategori
Gastroenterologi Allmänmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-173759DOI: 10.1186/s12875-020-01194-xISI: 000547011400006PubMedID: 32611307Scopus ID: 2-s2.0-85087470983OAI: oai:DiVA.org:umu-173759DiVA, id: diva2:1456079
Forskningsfinansiär
Visare Norr, 467541Visare Norr, 557151Tillgänglig från: 2020-07-31 Skapad: 2020-07-31 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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Högberg, CeciliaKarling, PontusRutegård, JörgenLilja, Mikael

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