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C-reactive Protein and Future Risk of Clinical and Molecular Subtypes of Colorectal Cancer
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.ORCID-id: 0000-0002-2974-2003
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
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2020 (Engelska)Ingår i: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 29, nr 7, s. 1482-1491Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Inflammation has been implicated in colorectal cancer etiology, but the relationship between C-reactive protein (CRP) and colorectal cancer risk is unclear. We aimed to investigate the association between prediagnostic plasma CRP concentrations and the risk of clinical and molecular colorectal cancer subtypes.

Methods: We used prospectively collected samples from 1,010 matched colorectal cancer case-control pairs from two population-based cohorts in Northern Sweden, including 259 with repeated samples. Conditional logistic regression and linear mixed models were used to estimate relative risks of colorectal cancer, including subtypes based on BRAF and KRAS mutations, microsatellite instability status, tumor location, stage, lag time, and (using unconditional logistic regression) body mass index.

Results: CRP was not associated with colorectal cancer risk, regardless of clinical or molecular colorectal cancer subtype. For participants with advanced tumors and blood samples <5 years before diagnosis, CRP was associated with higher risk [OR per 1 unit increase in natural logarithm (In) transformed CRP, 1.32; 95% confidence interval (CI), 1.01-1.73]. CRP levels increased over time, but average time trajectories were similar for cases and controls (P-interaction = 0.19).

Conclusions: Our results do not support intertumoral heterogeneity as an explanation for previous inconsistent findings regarding the role of CRP in colorectal cancer etiology. The possible association in the subgroup with advanced tumors and shorter follow-up likely reflects undiagnosed cancer at baseline. Impact: Future efforts to establish the putative role of chronic, low-grade inflammation in colorectal cancer development will need to address the complex relationship between systemic inflammatory factors and tumor microenvironment, and might consider larger biomarker panels than CRP alone.

Ort, förlag, år, upplaga, sidor
American Association for Cancer Research , 2020. Vol. 29, nr 7, s. 1482-1491
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-174012DOI: 10.1158/1055-9965.EPI-19-1339ISI: 000552627400026PubMedID: 32317300Scopus ID: 2-s2.0-85087470027OAI: oai:DiVA.org:umu-174012DiVA, id: diva2:1459061
Tillgänglig från: 2020-08-19 Skapad: 2020-08-19 Senast uppdaterad: 2023-03-23Bibliografiskt granskad
Ingår i avhandling
1. Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
Öppna denna publikation i ny flik eller fönster >>Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
2020 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Inflammation och risk för kroniska sjukdomar med fokus på kolorektalcancer och inverkan av kostmönster
Ort, förlag, år, upplaga, sidor
Umeå, Sweden: Umeå university, 2020. s. 81
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2099
Nyckelord
nutritional epidemiology, dietary patterns, epidemiology, cancer, colorectal cancer, chronic low-grade inflammation, biomarkers, metabolomics, nutritionsepidemiologi, kostmönster, epidemiologi, cancer, kolorektalcancer, kronisk låggradig inflammation, biomarkörer, metabolomik
Nationell ämneskategori
Cancer och onkologi Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Näringslära
Forskningsämne
epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-176737 (URN)978-91-7855-366-2 (ISBN)978-91-7855-365-5 (ISBN)
Disputation
2020-12-11, Hörsal B, Unod T9, Norrlands universitetssjukhus, Umeå, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2020-11-20 Skapad: 2020-11-16 Senast uppdaterad: 2022-05-12Bibliografiskt granskad

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Bodén, StinaMyte, RobinSundkvist, AnneliZingmark, CarlLöfgren Burström, AnnaPalmqvist, RichardHarlid, Sophiavan Guelpen, Bethany

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Bodén, StinaMyte, RobinHarbs, JustinSundkvist, AnneliZingmark, CarlLöfgren Burström, AnnaPalmqvist, RichardHarlid, Sophiavan Guelpen, Bethany
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OnkologiPatologiWallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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Cancer Epidemiology, Biomarkers and Prevention
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