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Mechanisms underlying nontoxic indoor air health problems: a review
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
2020 (Engelska)Ingår i: International journal of hygiene and environmental health (Print), ISSN 1438-4639, E-ISSN 1618-131X, Vol. 226, artikel-id 113489Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Indoor air health problems of the type non-specific building-related symptoms (NBRS; formally called "sick-building syndrome") and chemical intolerance (CI; e.g. multiple chemical sensitivity) can in severe cases lead to significant disability and poor quality of life. Apart from suffering of the afflicted individuals, the productivity loss ascribed to environmental intolerances of this kind is very costly for society. Preventive measures and appropriate treatment call for understanding of the mechanism underlying NBRS and CI. Considerable similarities between NBRS and CI suggest that the two conditions at large share mechanisms. Since typical cases of these conditions cannot be explained by toxic exposure, the present objective is to describe underlying mechanisms of psychobiological nature for which there is well-developed theoretical ground and empirical support. Focus lies on the mechanisms neurogenic inflammation and neural sensitization. Apart from describing its basic mechanisms, neurogenic inflammation is reviewed in relation to NBRS and CI regarding neurogenic switching, activation of the autonomic nervous system and axon reflex as well as interaction effects between chemical irritants, allergens, and psychosocial stressors. In addition to describing various types of sensitization, empirical support for their role in NBRS and CI is reviewed. The mechanism classical conditioning, symptom misattribution and somatosensory amplification, and nocebo are also addressed. The review rounds off with a discussion on why only a subset of individuals exposed to these indoor environments develop NBRS and CI, and a discussion on integration of the presented mechanisms, accompanied by proposed hypotheses for future research.

Ort, förlag, år, upplaga, sidor
Elsevier, 2020. Vol. 226, artikel-id 113489
Nyckelord [en]
Non-specific building-related symptoms, Chemical intolerance, Neurogenic inflammation, Neural sensitization, Classical conditioning, Nocebo
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Infektionsmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-174264DOI: 10.1016/j.ijheh.2020.113489ISI: 000531826100016PubMedID: 32163882Scopus ID: 2-s2.0-85081027345OAI: oai:DiVA.org:umu-174264DiVA, id: diva2:1459360
Projekt
HUSSTillgänglig från: 2020-08-19 Skapad: 2020-08-19 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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Nordin, Steven

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International journal of hygiene and environmental health (Print)
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologiInfektionsmedicin

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