Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Presence of hyaluronan in lung alveoli in severe Covid-19: an opening for new treatment options?
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.ORCID iD: 0000-0002-3822-0725
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
Show others and affiliations
2020 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 295, no 45, p. 15418-15422Article in journal (Refereed) Published
Abstract [en]

Severe corona virus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined.The aim of the study was to demonstrate if the lungs of fatal Covid-19 contain hyaluronan as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly.Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue.Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs.

Place, publisher, year, edition, pages
The American Society for Biochemistry and Molecular Biology (ASBMB) , 2020. Vol. 295, no 45, p. 15418-15422
Keywords [en]
COVID-19, autopsy, coronavirus, extracellular matrix, glycosaminoglycan, hyaluronan, lung, virus
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-175504DOI: 10.1074/jbc.AC120.015967ISI: 000591839400022PubMedID: 32978255Scopus ID: 2-s2.0-85095861098OAI: oai:DiVA.org:umu-175504DiVA, id: diva2:1472052
Funder
Swedish Heart Lung Foundation, 20200366Available from: 2020-09-30 Created: 2020-09-30 Last updated: 2023-05-09Bibliographically approved

Open Access in DiVA

fulltext(3203 kB)235 downloads
File information
File name FULLTEXT01.pdfFile size 3203 kBChecksum SHA-512
19446c6d0f98e10a9710c392db88552f4755de6d23a90e8361ae40bc9606edbf7ed8ca02add197cdcf2cc2896217b221fabe2b0f0e814c4393b19bbf8593667a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Hellman, UrbanEngström-Laurent, AnnaAhlm, ClasLaurent, ClaudeBlomberg, Anders

Search in DiVA

By author/editor
Hellman, UrbanKarlsson, Mats G.Engström-Laurent, AnnaAhlm, ClasLaurent, ClaudeBlomberg, Anders
By organisation
CardiologySection of MedicineDepartment of Clinical MicrobiologyOtorhinolaryngologyPulmonary Medicine
In the same journal
Journal of Biological Chemistry
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 235 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1103 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf