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Specific functions for Mediator complex subunits from different modules in the transcriptional response of Arabidopsis thaliana to abiotic stress
Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2020 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 10, no 1, article id 5073Article in journal (Refereed) Published
Abstract [en]

Adverse environmental conditions are detrimental to plant growth and development. Acclimation to abiotic stress conditions involves activation of signaling pathways which often results in changes in gene expression via networks of transcription factors (TFs). Mediator is a highly conserved co-regulator complex and an essential component of the transcriptional machinery in eukaryotes. Some Mediator subunits have been implicated in stress-responsive signaling pathways; however, much remains unknown regarding the role of plant Mediator in abiotic stress responses. Here, we use RNA-seq to analyze the transcriptional response of Arabidopsis thaliana to heat, cold and salt stress conditions. We identify a set of common abiotic stress regulons and describe the sequential and combinatorial nature of TFs involved in their transcriptional regulation. Furthermore, we identify stress-specific roles for the Mediator subunits MED9, MED16, MED18 and CDK8, and putative TFs connecting them to different stress signaling pathways. Our data also indicate different modes of action for subunits or modules of Mediator at the same gene loci, including a co-repressor function for MED16 prior to stress. These results illuminate a poorly understood but important player in the transcriptional response of plants to abiotic stress and identify target genes and mechanisms as a prelude to further biochemical characterization.

Place, publisher, year, edition, pages
Nature Publishing Group, 2020. Vol. 10, no 1, article id 5073
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:umu:diva-175085DOI: 10.1038/s41598-020-61758-wISI: 000563443900012PubMedID: 32193425Scopus ID: 2-s2.0-85082040402OAI: oai:DiVA.org:umu-175085DiVA, id: diva2:1472295
Funder
Knut and Alice Wallenberg Foundation, 2015-0056Swedish Research Council, 201603943Swedish Research Council, 2016-04319Swedish Foundation for Strategic Research , SB16-0089Available from: 2020-10-01 Created: 2020-10-01 Last updated: 2023-03-23Bibliographically approved

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Crawford, TimKaramat, FazeelatLehotai, NoraRentoft, MatildaBlomberg, JeanetteStrand, ÅsaBjörklund, Stefan

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Crawford, TimKaramat, FazeelatLehotai, NoraRentoft, MatildaBlomberg, JeanetteStrand, ÅsaBjörklund, Stefan
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Umeå Plant Science Centre (UPSC)Department of Plant PhysiologyDepartment of Medical Biochemistry and Biophysics
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