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Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0003-2135-9963
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany.
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2020 (English)In: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, E-ISSN 2352-8729, Vol. 12, no 1, article id e12110Article in journal (Refereed) Published
Abstract [en]

Introduction: The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear.

Methods: We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)–derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium.

Results: The change-change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non-carriers: N = 467, r = 0.073,P = .117). The linear relationship was significantly steeper for the carriers [t(629) =2.4, P = .013]. A similar trend toward a stronger change-change relation for carriers was seen in a subsample with more than two assessments.

Discussion: These findings provide evidence for a difference in hippocampus-memory association between ε4 carriers and non-carriers, thus highlighting how genetic factors modulate the translation of the AD-related pathophysiological cascade into cognitive deficits.

Place, publisher, year, edition, pages
John Wiley & Sons, 2020. Vol. 12, no 1, article id e12110
Keywords [en]
apolipoprotein (APOE) ε4, hippocampus, longitudinal, memory, MRI
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-175957DOI: 10.1002/dad2.12110ISI: 000707203600106Scopus ID: 2-s2.0-85100596109OAI: oai:DiVA.org:umu-175957DiVA, id: diva2:1476501
Funder
EU, Horizon 2020, 732592Available from: 2020-10-14 Created: 2020-10-14 Last updated: 2023-09-05Bibliographically approved

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Gorbach, TetianaPudas, SaraNyberg, Lars

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