Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studiesVisa övriga samt affilieringar
2020 (Engelska)Ingår i: Ageing Research Reviews, ISSN 1568-1637, E-ISSN 1872-9649, Vol. 64, artikel-id 101184Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.
Ort, förlag, år, upplaga, sidor
Elsevier, 2020. Vol. 64, artikel-id 101184
Nyckelord [en]
ageing, memory, longitudinal, brain, genetics, lifestyle, brain maintenance, cognitive reserve
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-176224DOI: 10.1016/j.arr.2020.101184ISI: 000595935300003PubMedID: 32992046Scopus ID: 2-s2.0-85092710312OAI: oai:DiVA.org:umu-176224DiVA, id: diva2:1478681
Forskningsfinansiär
Knut och Alice Wallenbergs Stiftelse, KAW-scholarEU, Horisont 2020, 732592EU, Horisont 2020, H2020-SC1-2016-2017EU, Horisont 2020, H2020-SC1-2016-RTDVetenskapsrådet, 2017- 00639Region VästerbottenDemensförbundetKnut och Alice Wallenbergs Stiftelse, KAW 2014.0205Vetenskapsrådet, 2015–02199Vetenskapsrådet, 2017- 03011Vetenskapsrådet, (2018-01729Forskningsrådet Formas, 942–2015-10992020-10-222020-10-222024-04-25Bibliografiskt granskad