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Carpal tunnel syndrome in acromegaly: a nationwide study
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för medicin.ORCID-id: 0000-0002-9501-6763
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Ortopedi.ORCID-id: 0000-0002-5469-2730
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2021 (Engelska)Ingår i: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 184, nr 2, s. 209-216Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a reported prevalence of 19–64%.We studied CTS in a large national cohort of patients with acromegaly and the temporal relationship between thetwo diagnoses.

Design: Retrospective, nationwide, cohort study including patients diagnosed with acromegaly in Sweden, 2005–2017,identified in the Swedish Healthcare Registries.

Methods: CTS (diagnosis and surgery in specialised healthcare) was analysed from 8.5 years before the diagnosis ofacromegaly until death or end of the study. Standardised incidence ratios (SIRs) with 95% CIs were calculated for CTSwith the Swedish population as reference.

Results: The analysis included 556 patients with acromegaly (50% women) diagnosed at mean (s.d.) age 50.1 (15.0)years. During the study period, 48 patients were diagnosed with CTS and 41 patients underwent at least one CTSsurgery. In the latter group, 35 (85%) were operated for CTS before the acromegaly diagnosis; mean interval (range)2.2 (0.3–8.5) years and the SIR for having CTS surgery before the diagnosis of acromegaly was 6.6 (4.8–8.9). Womenwith acromegaly had a higher risk for CTS than men (hazard ratio: 2.5, 95% CI: 1.3–4.7).

Conclusions: Patients with acromegaly had a 6-fold higher incidence for CTS surgery before the diagnosis of acromegalycompared with the general population. The majority of patients with both diagnoses were diagnosed with CTS priorto acromegaly. Increased awareness of signs of acromegaly in patients with CTS might help to shorten the diagnosticdelay in acromegaly, especially in women.

Ort, förlag, år, upplaga, sidor
Bioscientifica, 2021. Vol. 184, nr 2, s. 209-216
Nationell ämneskategori
Ortopedi
Identifikatorer
URN: urn:nbn:se:umu:diva-176621DOI: 10.1530/EJE-20-0530ISI: 000608421100007PubMedID: 33136549Scopus ID: 2-s2.0-85099711480OAI: oai:DiVA.org:umu-176621DiVA, id: diva2:1500032
Tillgänglig från: 2020-11-11 Skapad: 2020-11-11 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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Vouzouneraki, KonstantinaMukka, SebastianDahlqvist, Per

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