This article offers a reflection on the role of knowledge systems in the relations between models and practices of production and re-production of the social life of Kaiowa and Guaranicollectives in the border area of Brazil and Paraguay. The aim is to situate the Kaiowa and Guarani knowledge systems within the Teacher Education program of the Indigenous Licentiate program Teko Arandu, offered at the Indigenous Intercultural Faculty (FAIND) of the Federal University of Grande Dourados (UFGD). The text explores the Indigenous appropriation of academic knowledge and technologies that may have a result on cosmological revisions and strategies for claiming rights. These appropriations are agents of new forms of articulations between knowledge systems.