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Exploring the bacterial nano-universe
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0003-3964-3751
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0002-2991-8072
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).ORCID iD: 0000-0003-3492-3287
2020 (English)In: Current opinion in structural biology, ISSN 0959-440X, E-ISSN 1879-033X, Vol. 64, p. 166-173Article, review/survey (Refereed) Published
Abstract [en]

Since the days of the first acknowledged microscopist, Antonie van Leeuwenhoek, the 'animalcules', that is, bacteria and other microbes have been subject to increasingly detailed visualization. With the currently most sophisticated molecular imaging method; cryo electron tomography (Cryo-ET), we are reaching the milestone of being able to image an entire organism in a single dataset at nanometer resolution. Cryo-ET will enable the next revolution in our understanding of bacterial cells, their ultra-structure and intricate molecular nanomachines. Here, we highlight recent research discoveries based on constantly progressing technology developments. We discuss advantages and challenges of using Cryo-ET to visualize spatial structure of microorganisms and macromolecular complexes in their native environment.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 64, p. 166-173
National Category
Cell and Molecular Biology
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URN: urn:nbn:se:umu:diva-176785DOI: 10.1016/j.sbi.2020.07.002ISI: 000582131900024PubMedID: 32846309Scopus ID: 2-s2.0-85089728169OAI: oai:DiVA.org:umu-176785DiVA, id: diva2:1504006
Available from: 2020-11-26 Created: 2020-11-26 Last updated: 2023-03-24Bibliographically approved

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fulltext(2284 kB)288 downloads
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Söderholm, NiklasSingh, BirendraUhlin, Bernt EricSandblad, Linda

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Söderholm, NiklasSingh, BirendraUhlin, Bernt EricSandblad, Linda
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Molecular Infection Medicine Sweden (MIMS)Umeå Centre for Microbial Research (UCMR)Department of Molecular Biology (Faculty of Medicine)Department of Integrative Medical Biology (IMB)Department of Chemistry
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Current opinion in structural biology
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