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Relative Deficiency of Anti-Inflammatory N-Acylethanolamines Compared to Prostaglandins in Oral Lichen Planus
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).ORCID iD: 0000-0002-2883-5603
Umeå University, Faculty of Medicine, Department of Odontology. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).ORCID iD: 0000-0002-6658-7874
2020 (English)In: Biomedicines, E-ISSN 2227-9059, Vol. 8, no 11, article id 481Article in journal (Refereed) Published
Abstract [en]

Oral lichen planus (OLP) is a chronic inflammatory oromucosal disease. The N-acylethanolamines (NAEs), are a family of endogenous biologically active lipid mediators, with palmitoylethanolamide (PEA) being of particular interest here due to its anti-inflammatory and analgesic properties. In this study using oral mucosa biopsies from OLP patients and healthy controls, we investigated whether NAE synthesis was mobilized in response to the inflammation associated with OLP. PTGS2 levels, coding for cyclooxygenase-2 (COX-2), were increased approximately 4-fold in OLP compared to controls and a significant increase in the ratio of PTGS2 to NAPEPLD, the latter coding for a key enzyme in NAE synthesis, was seen. This was matched by an increased ratio of COX-2-derived prostaglandins to PEA in a second patient cohort. We conclude that there is an imbalance between prostaglandins and PEA in OLP, opening up the possibility that PEA might be a useful treatment for this disorder.

Place, publisher, year, edition, pages
MDPI, 2020. Vol. 8, no 11, article id 481
Keywords [en]
oral lichen planus, palmitoylethanolamide, N-acylethanolamine, prostaglandin, cyclooxygenase-2
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-178054DOI: 10.3390/biomedicines8110481ISI: 000592894000001PubMedID: 33172176Scopus ID: 2-s2.0-85096059627OAI: oai:DiVA.org:umu-178054DiVA, id: diva2:1513453
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Region VästerbottenAvailable from: 2020-12-30 Created: 2020-12-30 Last updated: 2023-03-24Bibliographically approved

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Rankin, LindaDanielsson, Karin P.Fowler, Christopher J

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