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Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology. Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
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2020 (English)In: Cancers, ISSN 2072-6694, Vol. 12, no 11, article id 3234Article, review/survey (Refereed) Published
Abstract [en]

Simple Summary Biomarkers for cancer diagnosis, prognosis and prediction are important tools and an urgent need in precision medicine for pancreatic cancer. In recent years, many experimental and clinical studies aimed at identifying new biomarkers for pancreatic ductal adenocarcinoma. In the review, we summarized current investigations on using novel protein markers, cell-free DNA, metabolome compounds, immune and stroma signatures and microbiome compositions as biomarkers for pancreatic cancer. Our comprehensive overview shows that although there are new promising biomarkers, CA 19-9 remains currently the only regularly used and validated biomarker for pancreatic cancer in clinical routine. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a dismal prognosis that is frequently diagnosed at an advanced stage. Although less common than other malignant diseases, it currently ranks as the fourth most common cause of cancer-related death in the European Union with a five-year survival rate of below 9%. Surgical resection, followed by adjuvant chemotherapy, remains the only potentially curative treatment but only a minority of patients is diagnosed with locally resectable, non-metastatic disease. Patients with advanced disease are treated with chemotherapy but high rates of treatment resistance and unfavorable side-effect profiles of some of the used regimens remain major challenges. Biomarkers reflect pathophysiological or physiological processes linked to a disease and can be used as diagnostic, prognostic and predictive tools. Thus, accurate biomarkers can allow for better patient stratification and guide therapy choices. Currently, the only broadly used biomarker for PDAC, CA 19-9, has multiple limitations and the need for novel biomarkers is urgent. In this review, we highlight the current situation, recent discoveries and developments in the field of biomarkers of PDAC and their potential clinical applications.

Place, publisher, year, edition, pages
MDPI, 2020. Vol. 12, no 11, article id 3234
Keywords [en]
pancreatic ductal adenocarcinoma, pancreatic cancer, protein biomarkers, microbiome biomarkers, metabolome biomarkers, DNA biomarkers, immune biomarkers
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-178091DOI: 10.3390/cancers12113234ISI: 000592841100001PubMedID: 33147766Scopus ID: 2-s2.0-85095417573OAI: oai:DiVA.org:umu-178091DiVA, id: diva2:1514629
Funder
Swedish Research Council, 2017-01531Region Västerbotten, RV-930167Region Västerbotten, VLL-832001Cancerforskningsfonden i Norrland, LP 20-2257Cancerforskningsfonden i Norrland, LP 18-2202Knut and Alice Wallenberg FoundationSwedish Cancer Society, CAN 2017/332Swedish Cancer Society, CAN 2017/827Region Stockholm, 20180661Available from: 2021-01-07 Created: 2021-01-07 Last updated: 2023-03-23Bibliographically approved

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Lindblad, StinaÖhlund, Daniel

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Khomiak, AndriiKordes, MaximilianLindblad, StinaMiksch, Rainer ChristophÖhlund, Daniel
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