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Polymer Adhesin Domains in Gram-Positive Cell Surface Proteins
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).ORCID iD: 0000-0001-6848-322x
2020 (English)In: Frontiers in Microbiology, E-ISSN 1664-302X, Vol. 11, article id 599899Article, review/survey (Refereed) Published
Abstract [en]

Surface proteins in Gram-positive bacteria are often involved in biofilm formation, host-cell interactions, and surface attachment. Here we review a protein module found in surface proteins that are often encoded on various mobile genetic elements like conjugative plasmids. This module binds to different types of polymers like DNA, lipoteichoic acid and glucans, and is here termed polymer adhesin domain. We analyze all proteins that contain a polymer adhesin domain and classify the proteins into distinct classes based on phylogenetic and protein domain analysis. Protein function and ligand binding show class specificity, information that will be useful in determining the function of the large number of so far uncharacterized proteins containing a polymer adhesin domain.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2020. Vol. 11, article id 599899
Keywords [en]
adhesin, Gram-positive, conjugation, biofilm, binding
National Category
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-178370DOI: 10.3389/fmicb.2020.599899ISI: 000596865300001PubMedID: 33324381Scopus ID: 2-s2.0-85097430192OAI: oai:DiVA.org:umu-178370DiVA, id: diva2:1516485
Funder
Swedish Research Council, 2016-03599Knut and Alice Wallenberg Foundation, SMK-1869NIH (National Institute of Health), R35 GM11807The Kempe Foundations, SMK-1869Available from: 2021-01-12 Created: 2021-01-12 Last updated: 2024-01-17Bibliographically approved

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Järvå, Michael A.Berntsson, Ronnie Per-Arne

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Järvå, Michael A.Berntsson, Ronnie Per-Arne
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Department of Medical Biochemistry and BiophysicsWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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Frontiers in Microbiology
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