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Systemic Markers of Injury and Injury Response are not Associated with Impaired Cerebrovascular Reactivity in Adult TBI: A CENTER-TBI Study
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2021 (Engelska)Ingår i: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 38, nr 7, s. 870-878Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The role of extra-cranial injury burden on cerebrovascular response in traumatic brain injury (TBI) is poorly documented. This study preliminarily assesses the association between admission features of extra-cranial injury burden on cerebrovascular reactivity. Using the CENTER-TBI HR ICU sub-study cohort, we evaluated those patients with both archived high-frequency digital intra-parenchymal ICP monitoring data of a minimum of 6 hours in duration, and the presence of a digital copy of their admission CT scan. Digital physiologic signals were processed for pressure reactivity index (PRx) and both the % time above defined PRx thresholds and mean hourly dose above threshold. This was conducted for both the first 72 hours and entire duration of recording. Admission extra-cranial injury characteristics and CT injury scores were obtained from the database, with quantitative contusion, edema, intraventricular hemorrhage (IVH) and extra-axial lesion volumes were obtained via semi-automated segmentation. Comparison between admission extra-cranial markers of injury and PRx metrics was conducted using Mann-U testing, and logistic regression techniques, adjusting for known CT injury metrics associated with impaired PRx. A total of 165 patients were included. Evaluating the entire ICU recording period, there was limited association between metrics of extra-cranial injury burden and impaired cerebrovascular reactivity. Using the first 72 hours of recording, admission temperature (p=0.042) and white blood cell % (WBC %) (p=0.013) were statistically associated with impaired cerebrovascular reactivity on Mann-U and univariate logistic regression. After adjusting for admission age, pupillary status, GCS motor score, pre-hospital hypoxia/hypotension and intra-cranial CT characteristics associated with impaired reactivity, temperature (p=0.021) and WBC % (p=0.013) remained significantly associated with mean PRx values above +0.25 and +0.35, respectively. Markers of extra-cranial injury burden do not appear to be strongly associated with impaired cerebrovascular reactivity in TBI, during both the initial and entire ICU stay. Keywords: autoregulation, cerebrovascular reactivity, extra-cranial injury, injury burden, TBI

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Mary Ann Liebert Inc. , 2021. Vol. 38, nr 7, s. 870-878
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-180046DOI: 10.1089/neu.2020.7304ISI: 000599863400001PubMedID: 33096953Scopus ID: 2-s2.0-85103754173OAI: oai:DiVA.org:umu-180046DiVA, id: diva2:1528688
Tillgänglig från: 2021-02-16 Skapad: 2021-02-16 Senast uppdaterad: 2021-07-13Bibliografiskt granskad

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Koskinen, Lars-Owe D.Sundström, Nina

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Koskinen, Lars-Owe D.Sundström, Nina
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Journal of Neurotrauma
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