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The Effects of Working Memory Updating Training in Parkinson's Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response
Umeå University, Faculty of Social Sciences, Department of Psychology.ORCID iD: 0000-0002-2348-1164
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark; Instituteof Sports Medicine Copenhagen (ISMC), Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark.ORCID iD: 0000-0002-4458-6475
Umeå University, Faculty of Social Sciences, Department of Psychology.ORCID iD: 0000-0003-0240-3690
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2021 (English)In: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 11, article id 587925Article in journal (Refereed) Published
Abstract [en]

In Parkinson's disease (PD), the fronto-striatal network is involved in motor and cognitive symptoms. Working memory (WM) updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to assess the feasibility of WM updating training in PD and measure change in cognition, movement and functional brain response in one individual with PD after WM updating training. A feasibility and single-subject (FL) study were performed in which patients with PD completed computerized WM updating training. The outcome measures were the pre-post changes in criterion and transfer cognitive tests; cognitive complaints; psychological health; movement kinematics; and task-related BOLD signal. Participants in the feasibility study showed improvements on the criterion tests at post-test. FL displayed the largest improvements on the criterion tests and smaller improvements on transfer tests. Furthermore, FL reported improved cognitive performance in everyday life. A shorter onset latency and smoother upper-limb goal-directed movements were measured at post-test, as well as increased activation within the striatum and decreased activation throughout the fronto-parietal WM network. This two-part study demonstrated that WM updating training is feasible to complete for PD patients and that change occurred in FL at post-test in the domains of cognition, movement and functional brain response.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2021. Vol. 11, article id 587925
Keywords [en]
Parkinson's disease, cognitive training, cognition, working memory, movement kinematics, functional magnetic resonance imaging
National Category
Neurosciences Neurology
Research subject
Neurology; Neurology
Identifiers
URN: urn:nbn:se:umu:diva-180163DOI: 10.3389/fpsyg.2020.587925ISI: 000612001800001PubMedID: 33519604Scopus ID: 2-s2.0-85100012546OAI: oai:DiVA.org:umu-180163DiVA, id: diva2:1530417
Available from: 2021-02-22 Created: 2021-02-22 Last updated: 2023-05-03Bibliographically approved

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Eriksson Domellöf, MagdalenaBoraxbekk, Carl-JohanDomellöf, ErikRönnqvist, LouiseBäckström, DavidForsgren, Lars

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Eriksson Domellöf, MagdalenaBoraxbekk, Carl-JohanDomellöf, ErikRönnqvist, LouiseBäckström, DavidForsgren, Lars
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