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Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
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2021 (English)In: Nature Communications, E-ISSN 2041-1723, Vol. 12, no 1, article id 721Article in journal (Refereed) Published
Abstract [en]

Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.

Place, publisher, year, edition, pages
Nature Research , 2021. Vol. 12, no 1, article id 721
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-180521DOI: 10.1038/s41467-021-21057-yISI: 000616941000002PubMedID: 33526780Scopus ID: 2-s2.0-85100257409OAI: oai:DiVA.org:umu-180521DiVA, id: diva2:1531059
Funder
EU, Horizon 2020, 732592The Research Council of Norway, 249931
Note

Correction: Roe, J.M., Vidal-Piñeiro, D., Sørensen, Ø. et al. Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nat Commun 13, 834 (2022). DOI: 10.1038/s41467-022-28514-2

Available from: 2021-02-25 Created: 2021-02-25 Last updated: 2023-09-05Bibliographically approved

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Nyberg, LarsPudas, Sara

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