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Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium
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2021 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 31, no 4, p. 1953-1969Article in journal (Refereed) Published
Abstract [en]

We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. "PSQI # 1 Subjective sleep quality" and "PSQI #5 Sleep disturbances" were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with "PSQI #5 Sleep disturbances" emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.

Place, publisher, year, edition, pages
Oxford University Press, 2021. Vol. 31, no 4, p. 1953-1969
Keywords [en]
aging, atrophy, cortex, sleep
National Category
Neurosciences Other Medical Sciences not elsewhere specified Psychology
Identifiers
URN: urn:nbn:se:umu:diva-181486DOI: 10.1093/cercor/bhaa332ISI: 000637029100007PubMedID: 33236064Scopus ID: 2-s2.0-85102911000OAI: oai:DiVA.org:umu-181486DiVA, id: diva2:1537033
Funder
EU, European Research Council, 732592Available from: 2021-03-13 Created: 2021-03-13 Last updated: 2024-03-20Bibliographically approved

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Nyberg, LarsPudas, Sara

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Umeå Centre for Functional Brain Imaging (UFBI)Department of Radiation Sciences
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Cerebral Cortex
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