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MAIT cell activation is associated with disease severity markers in acute hantavirus infection
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
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2021 (English)In: Cell Reports Medicine, E-ISSN 2666-3791 , Vol. 2, no 3, article id 100220Article in journal (Refereed) Published
Abstract [en]

Hantaviruses are zoonotic RNA viruses that cause severe acute disease in humans. Infected individuals have strong inflammatory responses that likely cause immunopathology. Here, we studied the response of mucosal-associated invariant T (MAIT) cells in peripheral blood of individuals with hemorrhagic fever with renal syndrome (HFRS) caused by Puumala orthohantavirus, a hantavirus endemic in Europe. We show that MAIT cell levels decrease in the blood during HFRS and that residual MAIT cells are highly activated. This activation correlates with HFRS severity markers. In vitro activation of MAIT cells by hantavirus-exposed antigen-presenting cells is dependent on type I interferons (IFNs) and independent of interleukin-18 (IL-18). These findings highlight the role of type I IFNs in virus-driven MAIT cell activation and suggest a potential role of MAIT cells in the disease pathogenesis of viral infections.

Place, publisher, year, edition, pages
Saunders Elsevier, 2021. Vol. 2, no 3, article id 100220
Keywords [en]
cytokines, endothelial cells, hantavirus, hemorrhagic fever with renal syndrome, IL-6, MAIT cells, monocytes, Puumala orthohantavirus, T cells, type I interferons
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-181737DOI: 10.1016/j.xcrm.2021.100220ISI: 000642329200009Scopus ID: 2-s2.0-85102337267OAI: oai:DiVA.org:umu-181737DiVA, id: diva2:1539268
Available from: 2021-03-23 Created: 2021-03-23 Last updated: 2023-09-05Bibliographically approved

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Kerkman, PriscillaWigren, JuliaForsell, Mattias N. E.Ahlm, Clas

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