Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniaeVisa övriga samt affilieringar
2021 (Engelska)Ingår i: Journal of Alzheimer's Disease Reports, E-ISSN 2542-4823, Vol. 5, nr 1, s. 229-235Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Background: Amyloid-β (Aβ), the key constituent of Alzheimer’s disease (AD) plaques, has antimicrobial properties.
Objective: To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and C. pneumoniae.
Methods: Plasma from 339 AD cases, obtained on average 9.4 years (±4.00) before diagnosis, and their matched controls were analyzed for Aβ40 and Aβ42 concentrations with Luminex xMAP technology and INNOBIA plasma Aβ-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG. Follow-up samples were available for 150 of the cases.
Results: Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG did not correlate with concentrations of Aβ42 or Aβ40 in cases or controls.
Conclusion: Levels of plasma Aβ were not associated with antibodies against different AD-related pathogens.
Ort, förlag, år, upplaga, sidor
IOS Press, 2021. Vol. 5, nr 1, s. 229-235
Nyckelord [en]
Alzheimer’s disease, amyloid-β peptides, Chlamydophila pneumoniae, cytomegalovirus, dementia, Herpes simplex, nested case-control study
Nationell ämneskategori
Gerontologi, medicinsk/hälsovetenskaplig inriktning
Identifikatorer
URN: urn:nbn:se:umu:diva-182612DOI: 10.3233/ADR-210008ISI: 000651079100025Scopus ID: 2-s2.0-85103991159OAI: oai:DiVA.org:umu-182612DiVA, id: diva2:1547584
2021-04-272021-04-272023-09-05Bibliografiskt granskad