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O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA.
2014 (Engelska)Ingår i: Glycobiology of the Nervous System / [ed] Yu R., Schengrund CL., New York: Springer, 2014, s. 343-366Kapitel i bok, del av antologi (Övrigt vetenskapligt)
Abstract [en]

O-GlcNAc is the attachment of β-N-acetylglucosamine to the hydroxyl group of serine and threonine in nuclear and cytoplasmic proteins. It is generally not further elongated but exists as a monosaccharide that can be rapidly added or removed. Thousands of proteins involved in gene transcription, protein translation, and degradation as well as the regulation of signal transduction contain O-GlcNAc. Brain is one of the tissues where O-GlcNAc is most highly expressed and deletion of neuronal O-GlcNAc leads to death early in development. O-GlcNAc is also important for normal adult brain function, where dynamic processes like learning and memory at least in part depend on the modification of specific proteins by O-GlcNAc. Conversely, too much or too little O-GlcNAc on other proteins participates in neurodegenerative processes underlying diseases such as Alzheimer’s and Parkinson’s. In this chapter, we describe the expression and regulation of O-GlcNAc in the nervous system.

Ort, förlag, år, upplaga, sidor
New York: Springer, 2014. s. 343-366
Serie
Advances in Neurobiology ; 9
Nyckelord [en]
O-linked N-acetylglucosamine, O-GlcNAc, Learning and memory, Neurodegeneration, Alzheimer’s disease, Signaling, Nutrient sensing, Post-translational modifications
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-182714DOI: 10.1007/978-1-4939-1154-7_16PubMedID: 25151387ISBN: 978-1-4939-1153-0 (tryckt)ISBN: 978-1-4939-1154-7 (digital)OAI: oai:DiVA.org:umu-182714DiVA, id: diva2:1548794
Tillgänglig från: 2021-05-03 Skapad: 2021-05-03 Senast uppdaterad: 2021-12-20Bibliografiskt granskad

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Lagerlöf, Olof

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