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Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease
Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
2011 (Engelska)Ingår i: Annual Review of Biochemistry, ISSN 0066-4154, E-ISSN 1545-4509, Vol. 50, s. 825-858Artikel i tidskrift (Övrigt vetenskapligt) Published
Abstract [en]

O-GlcNAcylation is the addition of β-D-N-acetylglucosamine to serine or threonine residues of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not discovered until the early 1980s and still remains difficult to detect and quantify. Nonetheless, O-GlcNAc is highly abundant and cycles on proteins with a timescale similar to protein phosphorylation. O-GlcNAc occurs in organisms ranging from some bacteria to protozoans and metazoans, including plants and nematodes up the evolutionary tree to man. O-GlcNAcylation is mostly on nuclear proteins, but it occurs in all intracellular compartments, including mitochondria. Recent glycomic analyses have shown that O-GlcNAcylation has surprisingly extensive cross talk with phosphorylation, where it serves as a nutrient/stress sensor to modulate signaling, transcription, and cytoskeletal functions. Abnormal amounts of O-GlcNAcylation underlie the etiology of insulin resistance and glucose toxicity in diabetes, and this type of modification plays a direct role in neurodegenerative disease. Many oncogenic proteins and tumor suppressor proteins are also regulated by O-GlcNAcylation. Current data justify extensive efforts toward a better understanding of this invisible, yet abundant, modification. As tools for the study of O-GlcNAc become more facile and available, exponential growth in this area of research will eventually take place.

Ort, förlag, år, upplaga, sidor
2011. Vol. 50, s. 825-858
Nyckelord [en]
O-GlcNAc, translation, diabetes, Alzheimer's disease, cancer
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Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-182716DOI: 10.1146/annurev-biochem-060608-102511OAI: oai:DiVA.org:umu-182716DiVA, id: diva2:1548798
Forskningsfinansiär
NIH (National Institute of Health), R01 CA42486NIH (National Institute of Health), R01 DK61671Tillgänglig från: 2021-05-03 Skapad: 2021-05-03 Senast uppdaterad: 2022-10-31Bibliografiskt granskad

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Lagerlöf, Olof

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