Individual’s beliefs about the nature of knowing and learning have been investigated under the label of epistemic beliefs. Although the area of epistemic beliefs is still growing, only a few studies deal with school children. A valuable research approach in this area is classifying students in more homogeneous groups according as it is done in Latent Profil Analyses. Therefore, we investigated 3088 secondary students across grades 5 to 12 with LTAs. We found three distinctive profiles (‘sophisticated’, ‘evidence-based/dynamic’, ‘multiplist’) according to students’ science-related epistemic beliefs. As a justification for this approach, results show several differences between these profiles regarding school and background variables, cognitive outcomes in general and in science as well as science related motivational characteristics.