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Posture-dependent collapse of the optic nerve subarachnoid space: A combined MRI and modeling study
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-1141-5143
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-3423-2083
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0001-6784-1945
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-1313-0934
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2021 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 62, no 4, article id 26Article in journal (Refereed) Published
Abstract [en]

PURPOSE: We hypothesize that a collapse of the optic nerve subarachnoid space (ONSAS) in the upright posture may protect the eyes from large translamina cribrosa pressure differences (TLCPD) believed to play a role in various optic nerve diseases (e.g., glaucoma). In this study, we combined magnetic resonance imaging (MRI) and mathematical modeling to investigate this potential ONSAS collapse and its effects on the TLCPD.

METHODS: First, we performed MRI on six healthy volunteers in 6° head-down tilt (HDT) and 13° head-up tilt (HUT) to assess changes in ONSAS volume (measured from the eye to the optic canal) with changes in posture. The volume change reflects optic nerve sheath (ONS) distensibility. Second, we used the MRI data and mathematical modeling to simulate ONSAS pressure and the potential ONSAS collapse in a 90° upright posture.

RESULTS: The MRI showed a 33% decrease in ONSAS volume from the HDT to HUT (P < 0.001). In the upright posture, the simulations predicted an ONSAS collapse 25 mm behind lamina cribrosa, disrupting the pressure communication between the ONSAS and the intracranial subarachnoid space. The collapse reduced the simulated postural increase in TLCPD by roughly 1 mm Hg, although this reduction was highly sensitive to ONS distensibility, varying between 0 and 4.8 mm Hg when varying the distensibility by ± 1 SD.

CONCLUSIONS: The ONSAS volume along the optic nerve is posture dependent. The simulations supported the hypothesized ONSAS collapse in the upright posture and showed that even small changes in ONS stiffness/distensibility may affect the TLCPD.

Place, publisher, year, edition, pages
Association for Research in Vision and Ophthalmology , 2021. Vol. 62, no 4, article id 26
Keywords [en]
Glaucoma, Glymphatics, Optic nerve subarachnoid space, Posture, Translaminar pressure
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:umu:diva-183129DOI: 10.1167/iovs.62.4.26ISI: 000696094600012PubMedID: 33877263Scopus ID: 2-s2.0-85104948743OAI: oai:DiVA.org:umu-183129DiVA, id: diva2:1555086
Funder
Swedish National Space Board, 193/17Available from: 2021-05-17 Created: 2021-05-17 Last updated: 2024-01-15Bibliographically approved

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Holmlund, PetterStoverud, Karen-HeleneWåhlin, AndersWiklund, UrbanMalm, JanJóhannesson, GautiEklund, Anders

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Holmlund, PetterStoverud, Karen-HeleneWåhlin, AndersWiklund, UrbanMalm, JanJóhannesson, GautiEklund, Anders
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Radiation PhysicsUmeå Centre for Functional Brain Imaging (UFBI)NeurosciencesWallenberg Centre for Molecular Medicine at Umeå University (WCMM)Ophthalmology
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