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Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study
Umeå universitet, Medicinska fakulteten, Institutionen för omvårdnad. Regional Cancer Center, Stockholm-Gotland, Sweden; Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.ORCID-id: 0000-0001-5747-853x
Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology, Uppsala University, Uppsala, Sweden.
Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.
Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology, Uppsala University, Uppsala, Sweden.
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2021 (Engelska)Ingår i: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 60, nr 11, s. 1459-1465Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: Cancer patients are considered to have a higher risk of dying and developing severe Coronavirus Disease 2019 (COVID-19). To date, there are few studies including co-morbidities and sociodemographic factors when investigating the outcome of COVID-19 in a cohort of cancer patients. In this study, we analyzed cancer patients that have been hospitalized due to COVID-19 during the first wave of the pandemic in Sweden to investigate the impact of COVID-19 on mortality and morbidity.

Patients and methods: We retrospectively collected data on all patients with cancer that were hospitalized due to COVID-19-related symptoms at Uppsala University Hospital and Karolinska University Hospital between 1 March and 31 August 2020. The primary endpoint was COVID-19-related death and the secondary endpoint was to describe COVID-19 severity, defined as symptom severity (grades 0–4) and length of stay (LOS) at the university hospitals.

Results: In total, 193 patients were included among which 31% died due to COVID-19 and 8% died of other causes. In a multivariable analysis, older age >70 (OR 3.6; 95% CI [1.8–7.3], p < 0.001) and male gender (OR 2.8 [1.4–5.8], p = 0.005) were factors associated with higher likelihood of COVID-19-related death. Several comorbidities ≥2 (OR 5.4 [2.0–14.3], p = 0.001) was independently associated with COVID-19 severity. Treatment with chemotherapy within 90 days prior to COVID-19 diagnosis were not associated with COVID-19-related death or severity.

Conclusion: Factors associated with higher likelihood of COVID-19-related death were older age and male gender. More severe COVID-19 symptoms were seen in patients with multiple comorbidities. We did not see any associations between COVID-19-related death or severity and recent treatment including chemotherapy. In summary, this supports a thorough assessment regarding potential risks with COVID-19 infection in patients with cancer, with a combination of individual risk factors in addition to cancer treatments.

Ort, förlag, år, upplaga, sidor
Taylor & Francis Group, 2021. Vol. 60, nr 11, s. 1459-1465
Nyckelord [en]
Cancer, chemotherapy, COVID-19, death, mortality
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-186594DOI: 10.1080/0284186X.2021.1958005ISI: 000680268000001PubMedID: 34334081Scopus ID: 2-s2.0-85111935651OAI: oai:DiVA.org:umu-186594DiVA, id: diva2:1584809
Tillgänglig från: 2021-08-13 Skapad: 2021-08-13 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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