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Genome reconstructions of metabolism of Plasmodium RBC and liver stages
Department of Genetics, Harvard Medical School, MA, Boston, United States; Wyss Institute for Biologically Inspired Engineering, MA, Boston, United States; Department of Chemical Engineering, Massachusetts Institute of Technology, MA, Cambridge, United States.
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). The Laboratory for Molecular Infection Medicine Sweden, Umeå, Sweden.ORCID iD: 0000-0003-1716-168x
2021 (English)In: Current Opinion in Microbiology, ISSN 1369-5274, E-ISSN 1879-0364, Vol. 63, p. 259-266Article, review/survey (Refereed) Published
Abstract [en]

Genome scale metabolic models (GEMs) offer a powerful means of integrating genome and biochemical information on an organism to make testable predictions of metabolic functions at different conditions and to systematically predict essential genes that may be targeted by drugs. This review describes how Plasmodium GEMs have become increasingly more accurate through the integration of omics and experimental genetic data. We also discuss how GEMs contribute to our increasing understanding of how Plasmodium metabolism is reprogrammed between life cycle stages.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 63, p. 259-266
National Category
Cell and Molecular Biology Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:umu:diva-187223DOI: 10.1016/j.mib.2021.08.006ISI: 000701810100036Scopus ID: 2-s2.0-85113532209OAI: oai:DiVA.org:umu-187223DiVA, id: diva2:1591765
Funder
Knut and Alice Wallenberg FoundationEU, European Research Council, 788516Available from: 2021-09-07 Created: 2021-09-07 Last updated: 2023-09-05Bibliographically approved

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Pandey, VikashBillker, Oliver

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Department of Molecular Biology (Faculty of Science and Technology)Molecular Infection Medicine Sweden (MIMS)
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