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Antiviral treatment associated with reduced risk of clinical Alzheimer's disease: A nested case-control study
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine. Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Section of Virology.ORCID iD: 0000-0001-9094-319x
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2021 (English)In: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, E-ISSN 2352-8737, Vol. 7, no 1, article id e12187Article in journal (Refereed) Published
Abstract [en]

Introduction: In this nested case-control study, we investigated if antiviral treatment given prior to onset of Alzheimer's disease (AD) could influence incident AD.

Methods: From a large population-based cohort study in northern Sweden, 262 individuals that later developed AD were compared to a non-AD matched control group with respect to prescriptions of herpes antiviral treatment. All included subjects were herpes simplex virus 1 (HSV1) carriers and the matching criteria were age, sex, apolipoprotein E genotype (ε4 allele carriership), and study sample start year.

Results: Among those who developed AD, 6 prescriptions of antivirals were found, compared to 20 among matched controls. Adjusted for length of follow-up, a conditional logistic regression indicated a difference in the risk for AD development between groups (odds ratio for AD with an antiviral prescription 0.287, P = .018).

Discussion: Antiviral treatment might possibly reduce the risk for later development of HSV1-associated AD.
Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 7, no 1, article id e12187
Keywords [en]
Alzheimer’s disease, antiviral treatment, apolipoprotein E gene, dementia, herpes simplex, major neurocognitive disorder, nested case-control study
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:umu:diva-187310DOI: 10.1002/trc2.12187ISI: 000750546300053Scopus ID: 2-s2.0-85114262531OAI: oai:DiVA.org:umu-187310DiVA, id: diva2:1591999
Funder
Region VästerbottenThe Dementia Association - The National Association for the Rights of the DementedAlzheimerfondenKnut and Alice Wallenberg FoundationForte, Swedish Research Council for Health, Working Life and Welfare, 2013-2056Available from: 2021-09-07 Created: 2021-09-07 Last updated: 2024-04-08Bibliographically approved

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Hemmingsson, Eva-StinaWeidung, BodilOlsson, JanJosefsson, MariaAdolfsson, RolfNyberg, LarsElgh, FredrikLövheim, Hugo

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Hemmingsson, Eva-StinaWeidung, BodilOlsson, JanJosefsson, MariaAdolfsson, RolfNyberg, LarsElgh, FredrikLövheim, Hugo
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Geriatric MedicineSection of VirologyCentre for Demographic and Ageing Research (CEDAR)Umeå Centre for Functional Brain Imaging (UFBI)StatisticsPsychiatryDepartment of PsychologyDiagnostic RadiologyWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions
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CiteExportLink to record
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