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P53 mRNA metabolism links with the DNA damage response
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology. RECAMO, Masaryk Memorial Cancer Institute, Zluty Kopec 7, Brno, Czech Republic.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2021 (English)In: Genes, E-ISSN 2073-4425, Vol. 12, no 9, article id 1446Article, review/survey (Refereed) Published
Abstract [en]

Human cells are subjected to continuous challenges by different genotoxic stress attacks. DNA damage leads to erroneous mutations, which can alter the function of oncogenes or tumor suppressors, resulting in cancer development. To circumvent this, cells activate the DNA damage response (DDR), which mainly involves cell cycle regulation and DNA repair processes. The tumor suppressor p53 plays a pivotal role in the DDR by halting the cell cycle and facilitating the DNA repair processes. Various pathways and factors participating in the detection and repair of DNA have been described, including scores of RNA-binding proteins (RBPs) and RNAs. It has become increasingly clear that p53’s role is multitasking, and p53 mRNA regulation plays a prominent part in the DDR. This review is aimed at covering the p53 RNA metabolism linked to the DDR and highlights the recent findings.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 12, no 9, article id 1446
Keywords [en]
ATM kinase, DNA damage response, MDM2, MRNA translation, P53, RNA metabolism, RNA-binding proteins
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:umu:diva-188154DOI: 10.3390/genes12091446ISI: 000699608200001Scopus ID: 2-s2.0-85115607311OAI: oai:DiVA.org:umu-188154DiVA, id: diva2:1601212
Available from: 2021-10-07 Created: 2021-10-07 Last updated: 2024-07-04Bibliographically approved

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Gnanasundram, Sivakumar VadivelBonczek, OndrejWang, LixiaoChen, SaFåhraeus, Robin

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