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The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation
Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, 4036 Stavanger, Norway.
Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, 4036 Stavanger, Norway.
Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, 4036 Stavanger, Norway.
Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway; Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.ORCID-id: 0000-0001-9347-5790
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2010 (Engelska)Ingår i: Journal of Cell Science, ISSN 0021-9533, E-ISSN 1477-9137, Vol. 123, nr 10, s. 1644-1651Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Mutations in the DJ-1 gene (also known as PARK7) cause inherited Parkinson's disease, which is characterized by neuronal death. Although DJ-1 is thought to be an antioxidant protein, the underlying mechanism by which loss of DJ-1 function contributes to cell death is unclear. Human DJ-1 and its Arabidopsis thaliana homologue, AtDJ-1a, are evolutionarily conserved proteins, indicating a universal function. To gain further knowledge of the molecular features associated with DJ-1 dysfunction, we have characterized AtDJ-1a. We show that AtDJ-1a levels are responsive to stress treatment and that AtDJ-1a loss of function results in accelerated cell death in aging plants. By contrast, transgenic plants with elevated AtDJ-1a levels have increased protection against environmental stress conditions, such as strong light, H2O2, methyl viologen and copper sulfate. We further identify superoxide dismutase 1 (SOD1) and glutathione peroxidase 2 (GPX2) as interaction partners of both AtDJ-1a and human DJ-1, and show that this interaction results in AtDJ-1a- and DJ-1-mediated cytosolic SOD1 activation in a copper-dependent fashion. Our data have highlighted a conserved molecular mechanism for DJ-1 and revealed a new protein player in the oxidative stress response of plants.

Ort, förlag, år, upplaga, sidor
The Company of Biologists , 2010. Vol. 123, nr 10, s. 1644-1651
Nyckelord [en]
Arabidopsis, Stress, DJ-1
Nationell ämneskategori
Cellbiologi Cell- och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-188654DOI: 10.1242/jcs.063222ISI: 000277357400005PubMedID: 20406884Scopus ID: 2-s2.0-77952353245OAI: oai:DiVA.org:umu-188654DiVA, id: diva2:1603814
Tillgänglig från: 2021-10-18 Skapad: 2021-10-18 Senast uppdaterad: 2021-10-18Bibliografiskt granskad

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Björkblom, Benny

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