Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Investigation of multiple populations highlight VEGFA polymorphisms to modulate anterior cruciate ligament injury
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Department of Orthopaedic Surgery, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; UCT Research Centre for Health through Physical Activity, Lifestyle and Sport, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa.
Show others and affiliations
2022 (English)In: Journal of Orthopaedic Research, ISSN 0736-0266, E-ISSN 1554-527X, Vol. 40, no 7, p. 1604-1612Article in journal (Refereed) Published
Abstract [en]

Polymorphisms in VEGFA and KDR encoding proteins have been associated with anterior cruciate ligament (ACL) injury risk. We leveraged a collective sample from Sweden, Poland, and Australia to investigate the association of functional polymorphisms in VEGFA and KDR with susceptibility to ACL injury risk. Using a case–control genetic association approach, polymorphisms in VEGFA and KDR were genotyped and haplotypes inferred from 765 controls, and 912 cases clinically diagnosed with ACL rupture. For VEGFA, there was a significant overrepresentation of the rs2010963 CC genotype (p = 0.0001, false discovery rate [FDR]: p = 0.001, odds ratio [OR]: 2.16, 95% confidence interval [CI]: 1.47–3.19) in the combined ACL group (18%) compared to the combined control group (11%). The VEGFA (rs699947 C/A, rs1570360 G/A, rs2010963 G/C) A-A-G haplotype was significantly (p = 0.010, OR: 0.85, 95% CI: 0.69–1.05) underrepresented in the combined ACL group (23%) compared to the combined control group (28%). In addition, the A-G-G construct was significantly (p = 0.036, OR: 0.81, 95% CI: 0.64–1.02) underrepresented in the combined ACL group (12%) compared to the combined CON group (16%). Our findings support the association of the VEGFA rs2010963 CC genotype with increased risk and (ii) the VEGFA A-A-G haplotype with a reduced risk, and are in alignment with the a priori hypothesis. Collectively identifying a genetic interval within VEGFA to be implicated in ACL risk modulation and highlight further the importance of vascular regulation in ligament biology.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 40, no 7, p. 1604-1612
Keywords [en]
ACL, angiogenesis, genetic association studies, ligament healing
National Category
Physiotherapy
Identifiers
URN: urn:nbn:se:umu:diva-188876DOI: 10.1002/jor.25192ISI: 000708263800001PubMedID: 34664319Scopus ID: 2-s2.0-85117215269OAI: oai:DiVA.org:umu-188876DiVA, id: diva2:1607301
Funder
Västerbotten County Council, VLL548501Västerbotten County Council, VLL-358901Swedish National Centre for Research in Sports, K2011‐69X‐21877‐01‐6Swedish National Centre for Research in Sports, K2014‐99X‐21876‐04‐4Available from: 2021-11-01 Created: 2021-11-01 Last updated: 2022-11-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Häger, Charlotte K.Nilsson, Kjell G.

Search in DiVA

By author/editor
Häger, Charlotte K.Nilsson, Kjell G.
By organisation
Department of Community Medicine and RehabilitationOrthopaedics
In the same journal
Journal of Orthopaedic Research
Physiotherapy

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 143 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf