Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity: The ARTSCAN 2 study
Department of ORL, Head & Neck Surgery, Skåne University Hospital, Lund University, Sweden.
Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund University, Sweden.
Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund University, Sweden.
Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund University, Sweden.
Visa övriga samt affilieringar
2022 (Engelska)Ingår i: Radiotherapy and Oncology, ISSN 0167-8140, E-ISSN 1879-0887, Vol. 166, s. 26-32Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background and purpose: An earlier prospective randomised multicentre study (ARTSCAN) in head and neck cancer patients that compared conventionally fractionated radiotherapy (CF) with accelerated radiotherapy (AF) was inconclusive. In the subgroup of oral cavity squamous cell cancer (OCSCC) a large absolute, but not statistically significant, difference in local control was seen in favour of AF. This difference was more pronounced in resectable tumours. The finding raised the hypothesis that AF could be beneficial for OCSCC patients. In addition, the longstanding controversy on pre- or postoperative radiotherapy was addressed.

Materials and methods: Patients with OCSCC, judged to withstand and likely benefit from combined therapy, were recruited. Subjects were randomised to either preoperative AF with 43 fractions given as a concomitant boost with two fractions/day to the tumour bearing volume to a total dose of 68 Gy in 4.5 weeks followed by surgery, or primary surgery with postoperative CF, total dose 60 or 66 Gy in 6–7 weeks. For patients whose tumours had high-risk features, 66 Gy and concomitant cisplatin was prescribed.

Results: 250 patients were randomised. Median follow-up was 5 years for locoregional control (LRC) and 9 years for overall survival (OS). There were no statistically significant differences between the two treatment arms regarding LRC and OS. LRC at five years was 73% (95% CI, 65–82) in preoperative AF and 78% (95% CI, 70–85) in postoperative CF. Toxicity was more pronounced in preoperative AF.

Conclusion: This study does not support that AF prior to surgery improves outcome in oral cavity cancer compared with postoperative CF.

Ort, förlag, år, upplaga, sidor
Elsevier, 2022. Vol. 166, s. 26-32
Nyckelord [en]
Head and neck cancer, Oral cancer, Preoperative and postoperative radiotherapy, Randomised trial, Squamous cell carcinoma
Nationell ämneskategori
Radiologi och bildbehandling Cancer och onkologi
Forskningsämne
onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-190146DOI: 10.1016/j.radonc.2021.11.008ISI: 000806055500005PubMedID: 34793864Scopus ID: 2-s2.0-85120304608OAI: oai:DiVA.org:umu-190146DiVA, id: diva2:1618510
Forskningsfinansiär
Cancerfonden, CAN2010/544Cancerfonden, CAN2012/668Tillgänglig från: 2021-12-09 Skapad: 2021-12-09 Senast uppdaterad: 2023-09-05Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Söderkvist, KarinWahlgren, MagnusZackrisson, Björn

Sök vidare i DiVA

Av författaren/redaktören
Söderkvist, KarinWahlgren, MagnusZackrisson, Björn
Av organisationen
OnkologiÖron- näs- och halssjukdomar
I samma tidskrift
Radiotherapy and Oncology
Radiologi och bildbehandlingCancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 152 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf