Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Inter- and intra-observer agreement on evaluating the presence of residual glandular tissue with magnetic resonance tomography following prophylactic mastectomy
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Show others and affiliations
2023 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 64, no 1, p. 67-73Article in journal (Refereed) Published
Abstract [en]

Background: There are no published international consensus or guideline documents regarding appropriate medical follow-up for women with hereditary increased risk of breast cancer who opt for prophylactic mastectomy. Moreover, it is not known whether breast magnetic resonance imaging (MRI) performed after a prophylactic mastectomy is a reproducible method for evaluating whether clinically relevant amounts of residual glandular tissue remains.

Purpose: To evaluate the inter- and intra-observer agreement on detecting residual glandular tissue with MRI. Material and Methods: In total, 40 women previously operated with prophylactic mastectomy underwent MRI and two breast radiologists (R1 and R2) independently assessed the presence of residual glandular tissue. Inter- and intra-rater agreements were assessed using Cohen's kappa (k).

Results: Residual glandular tissue was found in 69 of 248 quadrants (27.8%) and 32 of 62 breasts (51.6%) by R1 and 77 of 248 quadrants (31.1%) and 35 of 62 breasts (56.5%) by R2. The interrater agreement was observed to be moderate (k = 0.554) and the intra-rater agreement was observed to be substantial (k = 0.623).

Conclusion: In conclusion, the inter-and intra-rater observer agreement in regard to detection of residual glandular tissue was not excellent, which would be desirable for a method considered reproducible enough to be used as a surveillance tool after the surgical procedure in order to ensure that there is no relevant residual glandular tissue remaining warranting further follow-up. More research is needed, as well as establishment of precise protocols, before using the method in risk assessment of remaining glandular tissue and breast cancer risk.

Place, publisher, year, edition, pages
Sage Publications, 2023. Vol. 64, no 1, p. 67-73
Keywords [en]
magnetic resonance tomography, Prophylactic mastectomy, residual glandular tissue
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:umu:diva-190289DOI: 10.1177/02841851211058929ISI: 000727654700001PubMedID: 34851154Scopus ID: 2-s2.0-85120625717OAI: oai:DiVA.org:umu-190289DiVA, id: diva2:1619316
Available from: 2021-12-13 Created: 2021-12-13 Last updated: 2022-12-30Bibliographically approved

Open Access in DiVA

fulltext(1445 kB)111 downloads
File information
File name FULLTEXT02.pdfFile size 1445 kBChecksum SHA-512
f7a885205897fdd3844b99a0de0670a2e83ab55ddc88c53fbd7c7f6723f11247e8e82df00b304e566ef4d8387ca246cea50344dab1a0612ce9f1edabcb0c4fc2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Andersson, Magnus N.Tolocka, ErnstSund, MalinWiberg, Rebecca

Search in DiVA

By author/editor
Andersson, Magnus N.Tolocka, ErnstSund, MalinWiberg, Rebecca
By organisation
Hand SurgeryOncologySurgeryAnatomy
In the same journal
Acta Radiologica
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
Total: 153 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 263 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf