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Variation in Plasma Levels of TRAF2 Protein During Development of Squamous Cell Carcinoma of the Oral Tongue
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.ORCID-id: 0000-0002-6574-3628
Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
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2021 (Engelska)Ingår i: Frontiers in Oncology, E-ISSN 2234-943X, Vol. 11, artikel-id 753699Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

As early detection is crucial for improvement of cancer prognosis, we searched for biomarkers in plasma from individuals who later developed squamous cell carcinoma of the oral tongue (SCCOT) as well as in patients with an already established SCCOT. Levels of 261 proteins related to inflammation and/or tumor processes were measured using the proximity extension assay (PEA) in 179 plasma samples (42 collected before diagnosis of SCCOT with 81 matched controls; 28 collected at diagnosis of SCCOT with 28 matched controls). Statistical modeling tools principal component analysis (PCA) and orthogonal partial least square - discriminant analysis (OPLS-DA) were applied to provide insights into separations between groups. PCA models failed to achieve group separation of SCCOT patients from controls based on protein levels in samples taken prior to diagnosis or at the time of diagnosis. For pre-diagnostic samples and their controls, no significant OPLS-DA model was identified. Potentials for separating pre-diagnostic samples collected up to five years before diagnosis (n = 15) from matched controls (n = 28) were seen in four proteins. For diagnostic samples and controls, the OPLS-DA model indicated that 21 proteins were important for group separation. TNF receptor associated factor 2 (TRAF2), decreased in pre-diagnostic plasma (< 5 years) but increased at diagnosis, was the only protein showing altered levels before and at diagnosis of SCCOT (p-value < 0.05). Taken together, changes in plasma protein profiles at diagnosis were evident, but not reliably detectable in pre-diagnostic samples taken before clinical signs of tumor development. Variation in protein levels during cancer development poses a challenge for the identification of biomarkers that could predict SCCOT development.

Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2021. Vol. 11, artikel-id 753699
Nyckelord [en]
biomarker, plasma protein, prediction, tongue cancer, TRAF2
Nationell ämneskategori
Cancer och onkologi
Forskningsämne
onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-190577DOI: 10.3389/fonc.2021.753699ISI: 000727621900001PubMedID: 34888239Scopus ID: 2-s2.0-85120895549OAI: oai:DiVA.org:umu-190577DiVA, id: diva2:1621574
Forskningsfinansiär
Cancerfonden, 20 0754 PjF 01HTillgänglig från: 2021-12-20 Skapad: 2021-12-20 Senast uppdaterad: 2024-01-17Bibliografiskt granskad

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Gu, XiaolianWang, LixiaoSalehi, AmirSgaramella, NicolaZborayova, KatarinaNylander, Karin

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Gu, XiaolianWang, LixiaoSalehi, AmirSgaramella, NicolaZborayova, KatarinaNylander, Karin
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