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Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France.
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France.
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France.
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
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2021 (Engelska)Ingår i: BMC Medicine, E-ISSN 1741-7015, Vol. 19, nr 1, artikel-id 312Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2).

Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786).

Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed.

Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2021. Vol. 19, nr 1, artikel-id 312
Nyckelord [en]
Anthropometry, Breast cancer, Cross-sectional, Lifestyle, Metabolites
Nationell ämneskategori
Cancer och onkologi Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-190814DOI: 10.1186/s12916-021-02183-2ISI: 000728537600001PubMedID: 34886862Scopus ID: 2-s2.0-85121052328OAI: oai:DiVA.org:umu-190814DiVA, id: diva2:1623448
Tillgänglig från: 2021-12-29 Skapad: 2021-12-29 Senast uppdaterad: 2022-05-10Bibliografiskt granskad

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Vidman, LindaWinkvist, Anna

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