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Various pharmaceutical compounds often coexist in contaminated soils, yet little is known about how their interactions impact their mobility. We here show that two typical antibiotic and anti-inflammatory agents (nalidixic acid (NA) and niflumic acid (NFA)) commonly form dimers at several representative soil-and sediment-building minerals of contrasting composition and structure. Cobinding occurs in the form of a NFA-NA dimer stabilized by hydrogen bonding and van der Waals interactions. Using dynamic column experiments containing goethite-coated sand, we then demonstrated that presorbed NA effectively captured the otherwise weakly binding NFA from solution. Simultaneously injecting NA and NFA to presorbed NA enhanced even further both NA and NFA loadings, thereby altering their transport under flow-Through conditions. We also showed that environmental level amounts of natural organic matter can reduce the overall retention in column experiments, yet it does not suppress dimer formation. These environmentally relevant scenarios can be predicted using a new transport model that accounts for kinetics and cobinding reactions of NFA onto NA bound to goethite through metal-bonded, hydrogen-bonded, and outer-sphere complexes. These findings have important implications on assessing the fate of coexisting pharmaceutical compounds under dynamic flow conditions in contaminated soils.