The relationship between sign systems and the meaning potentials and affordances of multimodal technologies has received increasing attention in research on digital technology use in education. Students constantly adhere to and engage with semiotic shifts in sign systems when they work with digital technologies for learning purposes. This study explores students’ use of digital technologies in Swedish schools. We trace the way semiotic activity systems and cognitive processes are transformed and realized when students engage with shifts in sign systems into various meaning-making strategies. Methodologically, the study is based on a data set of video recordings, interviews, and observations of classroom practice in three primary schools. An analysis that draws on quantitative ethnography was applied to process and analyse the data. The main findings revealed that sign systems prompted by the technologies and the social space compete to some extent for students’ attention, and that technology design is monotonously rendering lower levels of mediation. These findings show that various sign system prompts need to be balanced and streamlined to support students in their meaning-making. This article conveys the importance of understanding sign systems, as they are the most common resources for technology-assisted learning, and change the prerequisites for meaning-making.