Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe
Nestlé Research, Vers-chez les-Blanc, Lausanne, Switzerland.
Nestlé Research, Vers-chez les-Blanc, Lausanne, Switzerland.
Nestlé Research, Vers-chez les-Blanc, Lausanne, Switzerland.
estlé Product Technology Center-Nutrition, Société des Produits Nestlé S.A., Vevey, Switzerland.
Visa övriga samt affilieringar
2022 (Engelska)Ingår i: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 61, s. 2167-2182Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: Human milk (HM) composition is influenced by factors, like maternal diet and body stores, among other factors. For evaluating the influence of maternal fatty acid (FA) status on milk FA composition, the correlation between FA content in HM and in maternal plasma, erythrocytes, and adipose tissue was investigated.

Methods: 223 European women who delivered at term, provided HM samples over first four months of lactation. Venous blood and adipose tissue (only from mothers who consented and underwent a C-section delivery) were sampled at delivery. FAs were assessed in plasma, erythrocytes, adipose tissue, and HM. Evolution of HM FAs over lactation and correlations between FA content in milk and tissues and between mother’s blood and cord blood were established.

Results: During lactation, arachidonic acid (ARA) and docosahexaenoic acid (DHA) significantly decreased, while linoleic acid (LA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA) remained stable. Positive correlations were observed between HM and adipose tissue for palmitic, stearic, oleic, and polyunsaturated fatty acids (PUFAs). Correlations were found between milk and plasma for oleic, LA, ARA, ALA, DHA, monounsaturated fatty acids (MUFAs), and PUFAs. No correlation was observed between erythrocytes and HM FAs. LA and ALA were more concentrated in maternal blood than in infant blood, contrary to ARA and DHA, supporting that biomagnification of LCPUFAs may have occurred during pregnancy.

Conclusions: These data show that maternal adipose tissue rather than erythrocytes may serve as reservoir of PUFAs and LCPUFAs for human milk. Plasma also supplies PUFAs and LCPUFAs to maternal milk. If both, adipose tissue and plasma PUFAs, are reflection of dietary intake, it is necessary to provide PUFAs and LCPUFAs during pregnancy or even before conception and lactation to ensure availability for mothers and enough supply for the infant via HM.

Ort, förlag, år, upplaga, sidor
Springer, 2022. Vol. 61, s. 2167-2182
Nyckelord [en]
Adipose tissue, DHA, Erythrocytes, Fatty acids, Human milk, Lactation, LCPUFA, Lipids, Nutrition, Plasma, Pregnancy
Nationell ämneskategori
Näringslära
Identifikatorer
URN: urn:nbn:se:umu:diva-192164DOI: 10.1007/s00394-021-02788-6ISI: 000746309500001PubMedID: 35072787Scopus ID: 2-s2.0-85123474837OAI: oai:DiVA.org:umu-192164DiVA, id: diva2:1634846
Tillgänglig från: 2022-02-03 Skapad: 2022-02-03 Senast uppdaterad: 2022-07-12Bibliografiskt granskad

Open Access i DiVA

fulltext(775 kB)172 nedladdningar
Filinformation
Filnamn FULLTEXT02.pdfFilstorlek 775 kBChecksumma SHA-512
64ed87b2d49f4b29aa5a539e48074c226b348b54417ac8f930f1f43c3263a55b15d85ee44aeed35d5eeb5758f76f2887a9ebc1cc8f197e375af8b4f950708f2a
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Domellöf, Magnus

Sök vidare i DiVA

Av författaren/redaktören
Domellöf, Magnus
Av organisationen
Pediatrik
I samma tidskrift
European Journal of Nutrition
Näringslära

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 201 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 217 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf