Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Base of tongue squamous cell carcinomas, outcome depending on treatment strategy and p16 status. A population-based study from the Swedish Head and Neck Cancer Register
Regional Cancer Centre West, Region Västra Götaland, Gothenburg, Sweden.
Regional Cancer Centre West, Region Västra Götaland, Gothenburg, Sweden; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden.
Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Oncology, Örebro University Hospital, Örebro, Sweden.
Visa övriga samt affilieringar
2022 (Engelska)Ingår i: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 61, nr 4, s. 433-440Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The base of tongue squamous cell carcinoma (BOTSCC) is mainly an HPV-related tumor. Radiotherapy (EBRT) ± concomitant chemotherapy (CT) is the backbone of the curatively intended treatment, with brachytherapy (BT) boost as an option. With four different treatment strategies in Sweden, a retrospective study based on the population-based Swedish Head and Neck Cancer Register (SweHNCR) was initiated.

Material and methods: Data on tumors, treatment and outcomes in patients with BOTSCC treated between 2008 and 2014 were validated through medical records and updated as needed. Data on p16 status were updated or completed with immunohistochemical analysis of archived tumor material. Tumors were reclassified according to the UICC 8th edition.

Results: Treatment was EBRT, EBRT + CT, EBRT + BT or EBRT + CT + BT in 151, 145, 82 and 167 patients respectively (n = 545). A p16 analysis was available in 414 cases; 338 were p16+ and 76 p16−. 5-year overall survival (OS) was 68% (95% CI: 64–72%), with76% and 37% for p16+ patients and p16− patients, respectively. An increase in OS was found with the addition of CT to EBRT for patients with p16+ tumors, stages II–III, but for patients with tumor stage I, p16+ (UICC 8) none of the treatment strategies was superior to EBRT alone.

Conclusion: In the present retrospective population-based study of BOTSCC brachytherapy was found to be of no beneficial value in curatively intended treatment. An increase in survival was found for EBRT + CT compared to EBRT alone in patients with advanced cases, stages II and III (UICC 8), but none of the regimes was significantly superior to EBRT as a single treatment modality for stage I (UICC 8), provided there was p16 positivity in the tumor. In the small group of patients with p16− tumors, a poorer prognosis was found, but the small sample size did not allow any comparisons between different treatment strategies.

Ort, förlag, år, upplaga, sidor
Taylor & Francis, 2022. Vol. 61, nr 4, s. 433-440
Nyckelord [en]
Base of tongue cancer, brachytherapy, HPV, radiotherapy, survival
Nationell ämneskategori
Cancer och onkologi
Forskningsämne
onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-192521DOI: 10.1080/0284186X.2022.2027516ISI: 000747591700001PubMedID: 35081863Scopus ID: 2-s2.0-85124079037OAI: oai:DiVA.org:umu-192521DiVA, id: diva2:1639496
Tillgänglig från: 2022-02-21 Skapad: 2022-02-21 Senast uppdaterad: 2023-03-23Bibliografiskt granskad

Open Access i DiVA

fulltext(1669 kB)117 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1669 kBChecksumma SHA-512
bb0069a05a75900f1f7de6f23b0c21ffe6f1af6f8b94c1d99c7147b2e2f35135b9fbc8db6529b0d1da0c563dd9fa00590b4ab061488fea1dc509511d496e3ca2
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Söderkvist, KarinZborayova, Katarina

Sök vidare i DiVA

Av författaren/redaktören
Söderkvist, KarinZborayova, Katarina
Av organisationen
OnkologiÖron- näs- och halssjukdomar
I samma tidskrift
Acta Oncologica
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 117 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 186 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf