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Education and Income Show Heterogeneous Relationships to Lifespan Brain and Cognitive Differences Across European and US Cohorts
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.
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2022 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 32, no 4, p. 839-854Article in journal (Refereed) Published
Abstract [en]

Higher socio-economic status (SES) has been proposed to have facilitating and protective effects on brain and cognition. We ask whether relationships between SES, brain volumes and cognitive ability differ across cohorts, by age and national origin. European and US cohorts covering the lifespan were studied (4-97 years, N = 500 000; 54 000 w/brain imaging). There was substantial heterogeneity across cohorts for all associations. Education was positively related to intracranial (ICV) and total gray matter (GM) volume. Income was related to ICV, but not GM. We did not observe reliable differences in associations as a function of age. SES was more strongly related to brain and cognition in US than European cohorts. Sample representativity varies, and this study cannot identify mechanisms underlying differences in associations across cohorts. Differences in neuroanatomical volumes partially explained SES-cognition relationships. SES was more strongly related to ICV than to GM, implying that SES-cognition relations in adulthood are less likely grounded in neuroprotective effects on GM volume in aging. The relatively stronger SES-ICV associations rather are compatible with SES-brain volume relationships being established early in life, as ICV stabilizes in childhood. The findings underscore that SES has no uniform association with, or impact on, brain and cognition.

Place, publisher, year, edition, pages
Oxford University Press, 2022. Vol. 32, no 4, p. 839-854
Keywords [en]
brain, cognitive function, lifespan, socioeconomic status
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-192643DOI: 10.1093/cercor/bhab248ISI: 000756694100001PubMedID: 34467389Scopus ID: 2-s2.0-85124576525OAI: oai:DiVA.org:umu-192643DiVA, id: diva2:1639652
Funder
EU, Horizon 2020, 732 592Knut and Alice Wallenberg FoundationNIH (National Institute of Health), U01DA041022, U01DA041028, U01DA041048, U01DA041089, U01DA041106, U01DA041117, U01DA041120, U01D A041134, U01DA041148, U01DA041156, U01DA041174, U24DA0411 23, U24DA041147, U01DA041093, U01DA041025Available from: 2022-02-22 Created: 2022-02-22 Last updated: 2023-09-05Bibliographically approved

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Nyberg, LarsPudas, Sara

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Umeå Centre for Functional Brain Imaging (UFBI)Department of Integrative Medical Biology (IMB)Diagnostic Radiology
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