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Intrasellar pressure in patients with pituitary adenoma – relation to tumour size and growth pattern
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
Department of Surgical Sciences Otorhinolaryngology, Uppsala University, Uppsala, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0002-9552-2957
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0003-3528-8502
2022 (Engelska)Ingår i: BMC Neurology, E-ISSN 1471-2377, Vol. 22, nr 1, artikel-id 82Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Only a few earlier publications on intrasellar pressure (ISP) have not been able to fully clarify any association between ISP and pituitary adenoma size and growth pattern. The aim of the study was to determine if intrasellar pressure (ISP) is elevated in patients with pituitary adenoma, and if the pressure is associated with tumour size and growth pattern.

Methods: The study included 100 patients operated for suspected pituitary adenoma, who have had their ISP measured intraoperatively. All adenomas were classified on the basis of Knosp and SIPAP, from which further classification of invasiveness was performed. MRT examinations were used to calculate the tumour volume and diameter in three axes.

Results: After exclusions, 93 cases were analysed. The mean ISP was 23.0 ± 8.4 mmHg. There were positive correlations between ISP and tumour volume and tumour diameters along all three axes. Coronal tumour diameter showed the strongest correlation with ISP elevation in a multivariate effect test. Adenomas classified as parasellar invasive (Knosp grade 3–4) showed higher mean ISP than adenomas considered as non-invasive (Knosp 0–2).

Conclusions: ISP is affected by tumour anatomy and correlates positively with tumour volume. Tumour width, i.e. diameter in the coronal plane, appears to be the measure that most strongly affects the ISP. This is confirmed by the association between ISP elevation and parasellar growth.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2022. Vol. 22, nr 1, artikel-id 82
Nyckelord [en]
Classification, Growth pattern, Intrasellar pressure, Pituitary adenoma
Nationell ämneskategori
Endokrinologi och diabetes Neurologi
Forskningsämne
neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-193216DOI: 10.1186/s12883-022-02601-9ISI: 000766553200003PubMedID: 35264140Scopus ID: 2-s2.0-85126078975OAI: oai:DiVA.org:umu-193216DiVA, id: diva2:1646417
Tillgänglig från: 2022-03-22 Skapad: 2022-03-22 Senast uppdaterad: 2022-10-10Bibliografiskt granskad

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Simander, GabrielLindvall, PeterKoskinen, Lars-Owe D.

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