Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study
Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain; ISGlobal, Hospital Clínic – University of Barcelona, Barcelona, Spain.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0003-4743-6365
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Show others and affiliations
2022 (English)In: Frontiers in Aging Neuroscience, ISSN 1663-4365, E-ISSN 1663-4365, Vol. 14, article id 795764Article in journal (Refereed) Published
Abstract [en]

Background: Loneliness is most prevalent during adolescence and late life and has been associated with mental health disorders as well as with cognitive decline during aging. Associations between longitudinal measures of loneliness and verbal episodic memory and brain structure should thus be investigated.

Methods: We sought to determine associations between loneliness and verbal episodic memory as well as loneliness and hippocampal volume trajectories across three longitudinal cohorts within the Lifebrain Consortium, including children, adolescents (N = 69, age range 10–15 at baseline examination) and older adults (N = 1468 over 60). We also explored putative loneliness correlates of cortical thinning across the entire cortical mantle.

Results: Loneliness was associated with worsening of verbal episodic memory in one cohort of older adults. Specifically, reporting medium to high levels of loneliness over time was related to significantly increased memory loss at follow-up examinations. The significance of the loneliness-memory change association was lost when eight participants were excluded after having developed dementia in any of the subsequent follow-up assessments. No significant structural brain correlates of loneliness were found, neither hippocampal volume change nor cortical thinning.

Conclusion: In the present longitudinal European multicenter study, the association between loneliness and episodic memory was mainly driven by individuals exhibiting progressive cognitive decline, which reinforces previous findings associating loneliness with cognitive impairment and dementia.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2022. Vol. 14, article id 795764
Keywords [en]
adolescence, cognitive decline, cortical thickness, episodic memory, hippocampus, loneliness
National Category
Neurosciences Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-193214DOI: 10.3389/fnagi.2022.795764ISI: 000771033900001Scopus ID: 2-s2.0-85126201039OAI: oai:DiVA.org:umu-193214DiVA, id: diva2:1646571
Available from: 2022-03-23 Created: 2022-03-23 Last updated: 2023-09-05Bibliographically approved

Open Access in DiVA

fulltext(1163 kB)106 downloads
File information
File name FULLTEXT01.pdfFile size 1163 kBChecksum SHA-512
fa856ab71778a8979af227440bc4b528046da7411387e376caf0a56d92f4be8c4ed6346998d2bb899950024d8467660a3923c52d1eebd5434e6fe01ac3e82d24
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Authority records

Andersson, MicaelStiernstedt, MikaelPudas, SaraNyberg, Lars

Search in DiVA

By author/editor
Andersson, MicaelStiernstedt, MikaelPudas, SaraNyberg, Lars
By organisation
Department of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)Diagnostic Radiology
In the same journal
Frontiers in Aging Neuroscience
NeurosciencesGerontology, specialising in Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 106 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 208 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf