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Brain Response to a Knee Proprioception Task Among Persons With Anterior Cruciate Ligament Reconstruction and Controls
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Section of Physiotherapy.ORCID iD: 0000-0002-6715-6208
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0003-1635-122x
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.ORCID iD: 0000-0002-4458-6475
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Section of Physiotherapy.ORCID iD: 0000-0003-0626-3154
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2022 (English)In: Frontiers in Human Neuroscience, E-ISSN 1662-5161, Vol. 16, article id 841874Article in journal (Refereed) Published
Abstract [en]

Knee proprioception deficits and neuroplasticity have been indicated following injury to the anterior cruciate ligament (ACL). Evidence is, however, scarce regarding brain response to knee proprioception tasks and the impact of ACL injury. This study aimed to identify brain regions associated with the proprioceptive sense of joint position at the knee and whether the related brain response of individuals with ACL reconstruction differed from that of asymptomatic controls. Twenty-one persons with unilateral ACL reconstruction (mean 23 months post-surgery) of either the right (n = 10) or left (n = 11) knee, as well as 19 controls (CTRL) matched for sex, age, height, weight and current activity level, performed a knee joint position sense (JPS) test during simultaneous functional magnetic resonance imaging (fMRI). Integrated motion capture provided real-time knee kinematics to activate test instructions, as well as accurate knee angles for JPS outcomes. Recruited brain regions during knee angle reproduction included somatosensory cortices, prefrontal cortex and insula. Neither brain response nor JPS errors differed between groups, but across groups significant correlations revealed that greater errors were associated with greater ipsilateral response in the anterior cingulate (r = 0.476, P = 0.009), supramarginal gyrus (r = 0.395, P = 0.034) and insula (r = 0.474, P = 0.008). This is the first study to capture brain response using fMRI in relation to quantifiable knee JPS. Activated brain regions have previously been associated with sensorimotor processes, body schema and interoception. Our innovative paradigm can help to guide future research investigating brain response to lower limb proprioception.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2022. Vol. 16, article id 841874
Keywords [en]
anterior cruciate ligament, anterior cruciate ligament reconstruction, knee, rehabilitation, position sense, magnetic resonance imaging, neuronal plasticity
National Category
Neurosciences Physiotherapy Orthopaedics
Identifiers
URN: urn:nbn:se:umu:diva-193644DOI: 10.3389/fnhum.2022.841874ISI: 000780202000001PubMedID: 35392122Scopus ID: 2-s2.0-85128106075OAI: oai:DiVA.org:umu-193644DiVA, id: diva2:1650848
Part of project
Knee Motor Control after Injury of the Anterior Cruciate Ligament: Clinical and Laboratory-Based Assessment in relation to Functional Performance, Proprioception and Associated Brain Activity, Swedish Research Council
Funder
Swedish Research Council, 2017-00892Konung Gustaf V:s och Drottning Victorias FrimurarestiftelseSwedish National Centre for Research in Sports, P2018-0104Swedish National Centre for Research in Sports, P2019-0068Region Västerbotten, VLL548501Region Västerbotten, VLL838421Novo NordiskAvailable from: 2022-04-08 Created: 2022-04-08 Last updated: 2024-01-17Bibliographically approved

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Strong, AndrewGrip, HelenaBoraxbekk, Carl-JohanSelling, JonasHäger, Charlotte

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