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Human in vivo evidence for striatal dopamine release in response to reward-prediction errors during reversal learning
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).ORCID-id: 0000-0003-2081-3562
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(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-194739OAI: oai:DiVA.org:umu-194739DiVA, id: diva2:1658357
Tillgänglig från: 2022-05-16 Skapad: 2022-05-16 Senast uppdaterad: 2022-05-16
Ingår i avhandling
1. Dopamine and the affective-cognitive gradient in the human striatum studied with multimodal brain imaging
Öppna denna publikation i ny flik eller fönster >>Dopamine and the affective-cognitive gradient in the human striatum studied with multimodal brain imaging
2022 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Both dopamine and the dopamine rich brain area, striatum, have been linked to behaviors related to incentives, motor action, and associative processing. Most of the cortex sends projections to the striatum, these connections have been described as a gradient organization representing a repertoire of functional behaviors. Although considerable research efforts have been made on the functions of dopamine, it is still unclear how and when it is released in the striatum in humans and what role it has for everyday behavior.

The overarching aim of this thesis is to contribute to our understanding of the role of striatal dopamine release during human behaviors relating to incentive, motor, and associative processing. Using a combination of multimodal brain imaging (positron emission tomography and functional magnetic resonance imaging) as well as cognitive modelling this thesis investigates: how a reproducible striatal response to incentives can be divided into behaviorally relevant components relating to affective and cognitive processes, how striatal dopamine release during motor action represent several component processes of behavior, and also provides evidence that striatal dopamine is released during reward prediction errors in humans. The results are consistent with an affective-cognitive gradient in the striatum and suggest that dopamine release into the striatal gradient might facilitate the integration of component processes into complex representations of behavior. The results of this thesis are based on healthy young individuals, however, aberrant dopamine signaling is a hallmark of several psychiatric and neurological diseases making it crucial to further understand the healthy dopamine system.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå universitet, 2022. s. 76
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2189
Nyckelord
dopamine, striatum, incentive, motor, associative, reinforcement learning, reward prediction error, positron emission tomography, functional magnetic resonance imaging, PET/MR, cognitive modelling
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
urn:nbn:se:umu:diva-194740 (URN)978-91-7855-824-7 (ISBN)978-91-7855-823-0 (ISBN)
Disputation
2022-06-10, Hörsal Betula, Målpunkt L, Norrlands universitetssjukhus, Umeå, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2022-05-20 Skapad: 2022-05-16 Senast uppdaterad: 2022-05-17Bibliografiskt granskad

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Grill, Filip

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Institutionen för strålningsvetenskaperUmeå centrum för funktionell hjärnavbildning (UFBI)
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