Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Dopamine and the affective-cognitive gradient in the human striatum studied with multimodal brain imaging
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).ORCID-id: 0000-0003-2081-3562
2022 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Both dopamine and the dopamine rich brain area, striatum, have been linked to behaviors related to incentives, motor action, and associative processing. Most of the cortex sends projections to the striatum, these connections have been described as a gradient organization representing a repertoire of functional behaviors. Although considerable research efforts have been made on the functions of dopamine, it is still unclear how and when it is released in the striatum in humans and what role it has for everyday behavior.

The overarching aim of this thesis is to contribute to our understanding of the role of striatal dopamine release during human behaviors relating to incentive, motor, and associative processing. Using a combination of multimodal brain imaging (positron emission tomography and functional magnetic resonance imaging) as well as cognitive modelling this thesis investigates: how a reproducible striatal response to incentives can be divided into behaviorally relevant components relating to affective and cognitive processes, how striatal dopamine release during motor action represent several component processes of behavior, and also provides evidence that striatal dopamine is released during reward prediction errors in humans. The results are consistent with an affective-cognitive gradient in the striatum and suggest that dopamine release into the striatal gradient might facilitate the integration of component processes into complex representations of behavior. The results of this thesis are based on healthy young individuals, however, aberrant dopamine signaling is a hallmark of several psychiatric and neurological diseases making it crucial to further understand the healthy dopamine system.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå universitet , 2022. , s. 76
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2189
Nyckelord [en]
dopamine, striatum, incentive, motor, associative, reinforcement learning, reward prediction error, positron emission tomography, functional magnetic resonance imaging, PET/MR, cognitive modelling
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-194740ISBN: 978-91-7855-824-7 (digital)ISBN: 978-91-7855-823-0 (tryckt)OAI: oai:DiVA.org:umu-194740DiVA, id: diva2:1658366
Disputation
2022-06-10, Hörsal Betula, Målpunkt L, Norrlands universitetssjukhus, Umeå, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2022-05-20 Skapad: 2022-05-16 Senast uppdaterad: 2022-05-17Bibliografiskt granskad
Delarbeten
1. Neural correlates of reward processing: Functional dissociation of two components within the ventral striatum
Öppna denna publikation i ny flik eller fönster >>Neural correlates of reward processing: Functional dissociation of two components within the ventral striatum
2021 (Engelska)Ingår i: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 11, nr 2, artikel-id e01987Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: Rewarding and punishing stimuli elicit BOLD responses in the affective division of the striatum. The responses typically traverse from the affective to the associative division of the striatum, suggesting an involvement of associative processes during the modulation of stimuli valance. In this study, we hypothesized that fMRI responses to rewards versus punishments in a guessing card game can be disassociated into two functional component processes that reflect the convergence of limbic and associative functional networks in the ventral striatum.

Methods: We used fMRI data of 175 (92 female) subjects from the human connectome project ' s gambling task, working memory task, and resting-state scans. A reward > punish contrast identified a ventral striatum cluster from which voxelwise GLM parameter estimates were entered into a k-means clustering algorithm. The k-means analysis supported separating the cluster into two spatially distinct components. These components were used as seeds to investigate their functional connectivity profile. GLM parameter estimates were extracted and compared from the task contrasts reward > punish and 2-back > 0-back from two ROIs in the ventral striatum and one ROI in hippocampus.

Results: The analyses converged to show that a superior striatal component, coupled with the ventral attention and frontal control networks, was responsive to both a modulation of cognitive control in working memory and to rewards, whereas the most inferior part of the ventral striatum, coupled with the limbic and default mode networks including the hippocampus, was selectively responsive to rewards.

Conclusion: We show that the fMRI response to rewards in the ventral striatum reflects a mixture of component processes of reward. An inferior ventral striatal component and hippocampus are part of an intrinsically coupled network that responds to reward-based processing during gambling. The more superior ventral striatal component is intrinsically coupled to networks involved with executive functioning and responded to both reward and cognitive control demands.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2021
Nyckelord
fMRI, functional connectivity, reward, ventral striatum
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
urn:nbn:se:umu:diva-178340 (URN)10.1002/brb3.1987 (DOI)000596747300001 ()33300306 (PubMedID)2-s2.0-85097315292 (Scopus ID)
Forskningsfinansiär
Vetenskapsrådet, 2015-03080Knut och Alice Wallenbergs Stiftelse, 2015.0277
Tillgänglig från: 2021-01-11 Skapad: 2021-01-11 Senast uppdaterad: 2022-05-16Bibliografiskt granskad
2. Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging
Öppna denna publikation i ny flik eller fönster >>Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging
Visa övriga...
2021 (Engelska)Ingår i: Frontiers in Human Neuroscience, E-ISSN 1662-5161, Vol. 15, artikel-id 733091Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Striatal dopamine is involved in facilitation of motor action as well as various cognitive and emotional functions. Positron emission tomography (PET) is the primary imaging method used to investigate dopamine function in humans. Previous PET studies have shown striatal dopamine release during simple finger tapping in both the putamen and the caudate. It is likely that dopamine release in the putamen is related to motor processes while dopamine release in the caudate could signal sustained cognitive component processes of the task, but the poor temporal resolution of PET has hindered firm conclusions. In this study we simultaneously collected [11C]Raclopride PET and functional Magnetic Resonance Imaging (fMRI) data while participants performed finger tapping, with fMRI being able to isolate activations related to individual tapping events. The results revealed fMRI-PET overlap in the bilateral putamen, which is consistent with a motor component process. Selective PET responses in the caudate, ventral striatum, and right posterior putamen, were also observed but did not overlap with fMRI responses to tapping events, suggesting that these reflect non-motor component processes of finger tapping. Our findings suggest an interplay between motor and non-motor-related dopamine release during simple finger tapping and illustrate the potential of hybrid PET-fMRI in revealing distinct component processes of cognitive functions.

Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2021
Nyckelord
finger tapping, PET, fMRI, dopamine, cognitive component, striatum
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
urn:nbn:se:umu:diva-194737 (URN)10.3389/fnhum.2021.733091 (DOI)000741902700001 ()34912200 (PubMedID)2-s2.0-85121204052 (Scopus ID)
Forskningsfinansiär
Vetenskapsrådet, 2015-03080Knut och Alice Wallenbergs Stiftelse, 2015.0277
Tillgänglig från: 2022-05-16 Skapad: 2022-05-16 Senast uppdaterad: 2024-01-17Bibliografiskt granskad
3. Human in vivo evidence for striatal dopamine release in response to reward-prediction errors during reversal learning
Öppna denna publikation i ny flik eller fönster >>Human in vivo evidence for striatal dopamine release in response to reward-prediction errors during reversal learning
Visa övriga...
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
urn:nbn:se:umu:diva-194739 (URN)
Tillgänglig från: 2022-05-16 Skapad: 2022-05-16 Senast uppdaterad: 2022-05-16

Open Access i DiVA

spikblad(121 kB)61 nedladdningar
Filinformation
Filnamn SPIKBLAD01.pdfFilstorlek 121 kBChecksumma SHA-512
64889e6b2eaf8a7de6a437532d40ee2c2d48a1e49787d0146cf0d06ef76b77ccb1aaabae38d953de05e208af16d9f01530a08f287a4788d53e894e93802744fd
Typ spikbladMimetyp application/pdf
fulltext(1455 kB)265 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1455 kBChecksumma SHA-512
5fef35181848cb400581640f051b3cee6092941d060a925aeb7d4b6dcc62dfa75450dba198db6b73bf9986e31cda2a732977be3149c02da6b8616afcdd224baa
Typ fulltextMimetyp application/pdf

Person

Grill, Filip

Sök vidare i DiVA

Av författaren/redaktören
Grill, Filip
Av organisationen
Institutionen för strålningsvetenskaperUmeå centrum för funktionell hjärnavbildning (UFBI)
Neurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 265 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

isbn
urn-nbn

Altmetricpoäng

isbn
urn-nbn
Totalt: 943 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf