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Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China.
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China.
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China.
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China.
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2022 (Engelska)Ingår i: Arthritis Research & Therapy , E-ISSN 1478-6362, Vol. 24, nr 1, artikel-id 129Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.

Methods: Fecal samples collected from OA and KBD patients were used to characterize the gut microbiota using 16S rDNA gene sequencing. To identify whether gut microbial changes at the species level are associated with the genes or functions of the gut bacteria between OA and KBD groups, metagenomic sequencing of fecal samples from OA and KBD subjects was performed.

Results: The OA group was characterized by elevated Epsilonbacteraeota and Firmicutes levels. A total of 52 genera were identified to be significantly differentially abundant between the two groups. The genera Raoultella, Citrobacter, Flavonifractor, g__Lachnospiraceae_UCG-004, and Burkholderia-Caballeronia-Paraburkholderia were more abundant in the OA group. The KBD group was characterized by higher Prevotella_9, Lactobacillus, Coprococcus_2, Senegalimassilia, and Holdemanella. The metagenomic sequencing showed that the Subdoligranulum_sp._APC924/74, Streptococcus_parasanguinis, and Streptococcus_salivarius were significantly increased in abundance in the OA group compared to those in the KBD group, and the species Prevotella_copri, Prevotella_sp._CAG:386, and Prevotella_stercorea were significantly decreased in abundance in the OA group compared to those in the KBD group by using metagenomic sequencing.

Conclusion: Our study provides a comprehensive landscape of the gut microbiota between OA and KBD patients and provides clues for better understanding the mechanisms underlying the pathogenesis of OA and KBD.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2022. Vol. 24, nr 1, artikel-id 129
Nyckelord [en]
Osteoarthritis, Kashin-Beck disease, 16S sequencing, Metagenomic sequencing, Microbiota
Nationell ämneskategori
Klinisk medicin Reumatologi och inflammation Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) Mikrobiologi
Forskningsämne
mikrobiologi; molekylär bioteknik (inst f cell- o molekylärbiologi); reumatologi
Identifikatorer
URN: urn:nbn:se:umu:diva-195579DOI: 10.1186/s13075-022-02819-5ISI: 000805592000003Scopus ID: 2-s2.0-85130915740OAI: oai:DiVA.org:umu-195579DiVA, id: diva2:1662293
Tillgänglig från: 2022-05-31 Skapad: 2022-05-31 Senast uppdaterad: 2024-07-04Bibliografiskt granskad

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Lammi, Mikko

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Arthritis Research & Therapy
Klinisk medicinReumatologi och inflammationMedicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)Mikrobiologi

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